Abstract
Krüppel is a member of the ‘gap’ class of segmentation genes of Drosophila melanogaster, mutations of which cause contiguous groups of segments of the fruitfly embryo to fail to develop. In the case of Krüppel mutant embryos, thoracic and anterior abdominal segments are deleted. The molecular cloning of the Krüppel locus will lead to an understanding of the crucial role that gap genes seem to have in early embryonic development. It has already allowed the identification of a blastoderm-specific Krüppel transcript and the phenotypic rescue of mutant embryos by injected cloned DNA.
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References
Lawrence, P. A. J. Embryol. exp. Morph. 30, 681–699 (1973).
Wieschaus, E. & Gehring, W. J. Devl Biol. 50, 249–263 (1976).
Schubiger, G. Devl Biol. 50, 476–488 (1976).
Capdevila, M. P. & Garcia-Bellido, A. Wilhelm Roux Arch. dev. Biol. 179, 125–143 (1976).
Szabad, J., Schüpbach, T. & Wieschaus, E. Devl Biol. 73, 265–271 (1979).
Wieschaus, E., Nüsslein-Volhard, C. & Jürgens, G. Wilhelm Roux Arch. dev. Biol. 193, 296–307 (1984).
Nüsslein-Volhard, C., Wieschaus, E. & Kluding, H. Wilhelm Roux Arch. dev. Biol 193, 267–282 (1984).
Jürgens, G., Kluding, H., Nüsslein-Volhard, C. & Wieschaus, E. Wilhelm Roux Arch. dev. Biol. 193, 283–295 (1984).
Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).
Gloor, H., Arch. Julius Klaus-Stift. 25, 38–44 (1954).
Wieschaus, E., Nüsslein-Volhard, C. & Kluding, H. Devl Biol. 104, 172–186 (1984).
Pirrotta, V., Jäckle, H. & Edström, J. E. in Genetic Engineering: Principles and Methods Vol. 5, 1–17 (Plenum, New York, 1983).
Bender, W., Spierer, P. & Hogness, D. S. J. molec. Biol. 168, 17–33 (1983).
Maniatis, T. et al. Cell 15, 687–701 (1978).
Wright, T. R. F., Bewley, G. C. & Sherald, A. F. Genetics 84, 287–311 (1976).
Steller, H. & Pirrotta, V. EMBO J. 3, 165–173 (1984).
Anderson, K. V. & Lengyel, J. Devl Biol. 70, 217–231 (1979).
Rubin, G. M. & Spradling, A. C. Science 218, 348–353 (1982).
Lohs-Schardin, M., Cremer, C. & Nüsslein-Volhard, C. Devl Biol. 73, 239–255 (1979).
Lindsley, D. L. & Grell, E. H. Publs Carnegie Instn 627 (1968).
Pirrotta, V., Hadfield, C. & Pretorius, G. H. J. EMBO J. 2, 927–934 (1983).
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 24, 5294–5399 (1979).
Jäckle, H. Wilhelm Roux Arch. dev. Biol. 188, 225–233 (1980).
Thomas, P. S. Proc. natn. Acad. sci. U.S.A. 77, 5201–5205 (1980).
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Preiss, A., Rosenberg, U., Kienlin, A. et al. Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo. Nature 313, 27–32 (1985). https://doi.org/10.1038/313027a0
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DOI: https://doi.org/10.1038/313027a0
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