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Nature of the Scrapie Agent

Abstract

There is evidence to suggest that the infectious disease scrapie is caused by an agent which does not depend on a nucleic acid for its ability to replicate. In the first of the two following articles it is suggested that scrapie can best be considered to arise from a replicable change in the structural pattern of a commonly occurring unit membrane. In the second article it is suggested that the agent is a protein and three possible mechanisms for its self-replication are proposed.

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References

  1. Stamp, J. T., Vet. Rec., 74, 357 (1962). Hunter, G. D., Nat. Inst. Nervous Diseases and Blindness Monograph, No. 2, 259 (1965).

    Google Scholar 

  2. Wildy, P., and Watson, D. H., Cold Spr. Harb. Symp. Quant. Biol., 27, 25 (1962).

    Article  CAS  Google Scholar 

  3. Alper, T., Haig, D. A., and Clarke, M. C., Biochem. Biophys. Res. Commun., 22, 278 (1966). Alper, T., Cramp, W. A., Haig, D. A., and Clarke, M. C., Nature, 214, 764 (1967).

    Article  CAS  Google Scholar 

  4. Pattison, I. H., J. Comp. Path., 75, 159 (1965).

    Article  CAS  Google Scholar 

  5. Chandler, R. L., Res. Vet. Sci., 4, 276 (1963).

    Article  Google Scholar 

  6. Hunter, G. D., and Millson, G. C., J. Gen. Microbiol., 37, 251 (1964).

    Article  CAS  Google Scholar 

  7. Mould, D. L., (personal communication).

  8. Hunter, G. D., and Millson, G. C., J. Comp. Path. (in the press).

  9. Gibbons, R. A., Hunter, G. D., and Kimberlin, R. H., (to be published).

  10. Hunter, G. D., and Millson, G. C., Res. Vet. Sci., 5, 149 (1964).

    Article  Google Scholar 

  11. Haig, D. A., and Clarke, M. C., Nat. Inst. Nervous Diseases and Blindness Monograph, No. 2, 215 (1965).

  12. Eklund, C. M., Hadlow, W. J., and Kennedy, R. C., Proc. Soc. Exp. Biol., NY, 112, 974 (1963).

    Article  Google Scholar 

  13. Mould, D. L., Dawson, A. M., and Smith, W., Res. Vet. Sci., 6, 151 (1965).

    Article  CAS  Google Scholar 

  14. Haig, D. A., and Clarke, M. C. (personal communication).

  15. Gordon, W. S., Vet. Rec., 58, 516 (1946).

    CAS  PubMed  Google Scholar 

  16. Hunter, G. D., and Millson, G. C. (unpublished results).

  17. Eklund, C. M., Kennedy, R. C., and Hadlow, W. J., J. Inf. Dis., 117, 15 (1967).

    Article  CAS  Google Scholar 

  18. Weil, R., Proc. US Nat. Acad. Sci., 49, 480 (1963).

    Article  ADS  CAS  Google Scholar 

  19. Kimberlin, R. H., and Hunter, G. D., J. Gen. Virology, 1, 115 (1967). Kimberlin, R. H. (to be published).

    Article  CAS  Google Scholar 

  20. Crick, F. H. C., Intern. Union Biochem., 33, 109 (1964).

    Google Scholar 

  21. Pazur, J., Kleppe, K., and Ball, E., Arch. Biochem. Biophys., 103, 515 (1963).

    Article  CAS  Google Scholar 

  22. Gardiner, A. C., Res. Vet. Sci., 7, 190 (1966).

    Article  CAS  Google Scholar 

  23. Allfrey, V. G., Littau, V. C., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 49, 414 (1963). Bukrinskaia, A. G., Gitelman, A. K., Burducheva, O., and Asadulaev, T. A., Dokl. Acad. Sci., USSR, 169, 469 (1966).

    Article  ADS  CAS  Google Scholar 

  24. Pattison, I. H., and Millson, G. C., Res. Vet. Sci., 71, 350 (1961). Paterson, P. Y., Nat. Inst. Nervous Diseases and Blindness Monograph, No. 2, 169 (1965).

    CAS  Google Scholar 

  25. Pattison, I. H., and Jones, K. M., Vet. Rec., 80, 2 (1967).

    Article  CAS  Google Scholar 

  26. Edstrom, R. D., and Heath, E. C., Biochem. Biophys. Res. Commun., 16, 576 (1964).

    Article  CAS  Google Scholar 

  27. Manners, D. J., Adv. Carbohydrate Chem., 17, 371 (1962).

    CAS  Google Scholar 

  28. Watkins, W. M., Immunol., 5, 245 (1962). Gibbons, R. A., Nature, 200, 665 (1963). Distler, J., and Roseman, S., Proc. US Nat. Acad. Sci., 51, 897 (1964). Watkins, W. M., Science, 152, 172 (1966).

    CAS  Google Scholar 

  29. Millson, G. C., J. Neurochem., 12, 461 (1965). Hunter, G. D., and Millson, G. C., J. Neurochem., 12, 375 (1966). Hunter, G. D., Millson, G. C., and Vockins, M. D., Biochem. J., 102, 43P (1967).

    Article  CAS  Google Scholar 

  30. Field, E. J., Brit. Med. J., ii, 564 (1966).

  31. Hunter, G. D., Millson, G. C., and Meek, G., J. Gen. Microbiol., 34, 319 (1964). Mould, D. L., Dawson, A. M., and Smith, W., Biochem. J., 91, 13P (1964).

    Article  CAS  Google Scholar 

  32. Davies, D. A. L., Ann. NY Acad. Sci., 120, 230 (1964).

    Article  ADS  CAS  Google Scholar 

  33. Gibbs, C. J., Gajdusek, D. C., and Morris, J. A., Nat. Inst. Nervous Diseases and Blindness Monogr., No. 2, 195 (1965). Pattison, I. H., and Sansom, B. F., Res. Vet. Sci., 5, 340 (1964).

    Google Scholar 

  34. Green, D. E., and Purdue, J. F., Proc. US Nat. Acad. Sci., 55, 1295 (1966). Maddy, A. H., Intern. Rev. Cytol., 20, 1 (1966).

    Article  ADS  CAS  Google Scholar 

  35. Hakomori, S., and Jeanloz, R., J. Biol. Chem., 236, 2827 (1961). Langley, O. K., and Ambrose, E. J., Nature, 204, 53 (1964). Cook, G. M. W., Laico, T., and Eylor, E. H., Proc. US Nat. Acad. Sci., 54, 247 (1965).

    CAS  PubMed  Google Scholar 

  36. Emmelot, P., and Bos, C. J., Biochim. Biophys. Acta, 99, 578 (1965); 115, 244 (1966). Gluck, L. J., and Guthens, S., Nature, 208, 88 (1965).

    Article  CAS  Google Scholar 

  37. Sanderson, A. R., and Davies, D. A. L., Nature, 200, 32 (1963).

    Article  ADS  CAS  Google Scholar 

  38. Beisson, J., and Sonneborn, T. M., Proc. US Nat. Acad. Sci., 53, 275 (1965).

    Article  ADS  CAS  Google Scholar 

  39. Gajdusek, D. C., New England J. Med., 276, 392 (1967).

    Article  CAS  Google Scholar 

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GIBBONS, R., HUNTER, G. Nature of the Scrapie Agent. Nature 215, 1041–1043 (1967). https://doi.org/10.1038/2151041a0

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