Rapid result has implications for outbreak preparedness as well as West Africa’s epidemic.

The success of an Ebola vaccine trial shows that clinical trials can be done under the difficult field conditions of an epidemic — if there is enough political and regulatory will.

The world is ill-prepared for the next epidemic or pandemic. But the horror of the Ebola outbreak in West Africa may drive change.

To prevent future epidemics, a new international effort must boost West Africa’s scientific and public-health capacity, says Christian Bréchot.

Testing Ebola treatments in West Africa's epidemic happened too late. Research response during future outbreaks must be more nimble, says Trudie Lang.

Leaders and health agencies are talking about 'lessons learned' from West Africa's Ebola epidemic. But a major push is needed to end the outbreak, urges Joanne Liu.

Study also demonstrates ability to develop a vaccine quickly during an outbreak.

Public-health officials make plans for how to speed up responses to tropical-disease outbreaks.

The World Health Organization announces the end of Ebola in Liberia, but the epidemic continues in nearby Sierra Leone and Guinea.

One of the most devastating consequences of the Ebola outbreak will be its impact on maternal health.

Health-care workers struggle to help people who have been traumatized by the epidemic.

A hospital in Sierra Leone has struggled to continue its research amid the worst Ebola outbreak in history.

Organizations seek to help patients reintegrate into society after recovering from the virus.

A front-line report from Sierra Leone examines efforts to change hearts and minds in West Africa’s villages.

Nature reports from the front line of the epidemic.

Scientists know a lot about the virus that causes Ebola — but there are many puzzles that they have yet to solve.

Establish principles for rapid and responsible data sharing in epidemics, urge Nathan L. Yozwiak, Stephen F. Schaffner and Pardis C. Sabeti.

Scaling up the recruitment of individuals who have recovered from infection deserves urgent consideration, argue Joshua M. Epstein, Lauren M. Sauer and colleagues.

A slowdown in new cases offers a chance for control efforts to get ahead of the epidemic.

Christopher J. M. Whitty and colleagues explain why the United Kingdom is funding many small community centres to isolate suspected cases in Sierra Leone.

Drawing on his experiences in previous outbreaks, David L. Heymann calls for rapid diagnosis, patient isolation, community engagement and clinical trials.

The Ebola outbreak in West Africa must be shut down now, or the disease will continue to spread.

The Ebola outbreak in West Africa has starkly exposed major gaps in plans to tackle emerging infectious diseases. Lessons must be learned.

Bottlenecks in testing samples for Ebola leave patients stranded for days in isolation wards and raise fears of seeking treatment, says J. Daniel Kelly.

Governments and research organizations must mobilize to end the West African outbreak.

Estimates of the probable impact of the outbreak show that existing stocks of potentially useful medicines are insufficient, says Oliver Brady.

An outbreak of Ebola highlights the difficulties of implementing public-health measures.

Rapid result has implications for outbreak preparedness as well as West Africa’s epidemic.

Study also demonstrates ability to develop a vaccine quickly during an outbreak.

Relief agency sees its mission expanding after leading response to West Africa epidemic.

Public-health officials make plans for how to speed up responses to tropical-disease outbreaks.

Genetic-sequence haul shows that the virus evolved differently — but no faster — than in previous epidemics.

Health agency’s annual meeting will address shortcomings in outbreak response highlighted by West Africa crisis.

The World Health Organization announces the end of Ebola in Liberia, but the epidemic continues in nearby Sierra Leone and Guinea.

Health-care workers struggle to help people who have been traumatized by the epidemic.

Despite a recent sharp drop in the overall number of Ebola cases, the situation remains precarious in West Africa.

A Guinean child who played with bats residing in a hollow tree later became the first known victim in the West African outbreak.

Mass drug distribution intended to reduce cases with Ebola-like symptoms.

Convalescent plasma therapy is trialled to fight Ebola, but could also be used for new and emerging pathogens.

Scientists in West Africa are racing to determine what immunization strategies could be most effective to contain the epidemic.

Trials of 'convalescent' plasma have begun in Liberia, and plasma and blood studies in Guinea and Sierra Leone will follow.

Rapid local diagnosis is essential for curbing spread.

With trials under way, scientists are working out how to give vaccines in affected regions.

A related vaccine is due to be tested in West Africa in 2015.

Experimental treatments to be tested in Guinea at Médecins Sans Frontières sites.

Public-health officials split on use of control groups in tests of experimental treatments.

Critics say timing of move could hamper response to Ebola epidemic.

Rate of infection in Liberia seems to plateau, raising questions over the usefulness of models in an outbreak.

Researchers say that exclusion of those recently in affected areas could undermine Ebola response.

As the virus continues to rampage in West Africa, Nature’s graphic offers a guide to the figures that matter.

Tapping into local cultures is key to curbing outbreak, says anthropologist Sharon Abramowitz.

Rapid 'contact tracing' will be key to containing the disease in west Africa.

Public-health experts fear that one epidemic may fuel another in West Africa.

US and UN mobilizations are welcome but overdue.

Obama pledges 3,000 personnel and roughly $750 million to stem outbreak in West Africa.

Experts say the possibility remains remote.

Therapy uses serum from disease survivors, but data on effectiveness is scarce.

Testing drugs in the middle of deadly disease outbreak is challenging but can be done.

ZMapp is the first treatment to completely protect animals after they show symptoms of disease.

World Health Organization projects 20,000 cases and requests US$490 million to control West Africa outbreak.

Outbreak likely originated with a single animal-to-human transmission.

Techniques used in the US to treat symptoms and subdue the virus in patients could work overseas, Bruce Ribner says.

Greater international assistance is needed to quell the epidemic, say health officials.

Animals spared from Marburg virus even when treated three days after infection.

Nature examines the risks and benefits of unproven Ebola treatments, as World Health Organization says it is ethical to use them in West African crisis.

World Health Organization announcement could shift focus to basic public health.

Although the virus is exerting a heavy toll in West Africa, it does not spread easily.

Logistics and lack of funds keep experimental drugs and vaccines from being used in Africa outbreak.

Ugandan laboratory helps to minimize number of cases.

Regime extends treatment window from minutes to hours.

Virus subtype suspected in Philippine swine.

Advance could help increase research into deadly virus.

The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous outbreaks and that the genetic diversity of the virus has increased substantially, with the emergence of several novel lineages.

An analysis of 85 Ebola virus sequences collected in Guinea from July to November 2014 provides insight into the evolution of the Ebola virus responsible for the epidemic in West Africa; the results show sustained transmission of three co-circulating lineages, each defined by multiple mutations.

Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.

A chimpanzee adenovirus-based vaccination approach elicits acute and long-term protection against ebolavirus challenge in nonhuman primates.

A new treatment, containing an optimized cocktail of three monoclonal antibodies against Ebola virus, provided full protection and disease reversal in rhesus monkeys when given under conditions in which controls succumbed by day 8; this new therapy may be a good candidate for treating Ebola virus infection in human patients.

A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure.

The search for therapeutics to treat infections by ebolaviruses and Marburg virus has focused on identifying compounds that interfere with viral entry into host cells. Here, White and Schornberg discuss recent studies that have identified Niemann–Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.