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In this supplement, the authors comprehensively review molecular and clinical evidence underlying the evolution of poly (ADP-ribose) polymerase (PARP) inhibitors in a journey spanning 50 years, which culminates in the recent licensing approval of the first oral PARP inhibitor, olaparib (Lynparzat™), for BRCA-mutated high-grade serous ovarian cancer. In addition, it discusses current UK procedures for BRCA testing of at-risk women and considers BRCA mutation genetic testing models for patients with ovarian cancer. Medical writing support was provided by Mudskipper and Nyxeon and funded by AstraZeneca.
