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The complexity of the human genome clearly emerged with the identification of several classes of non-coding RNAs. Within these, long-non-coding RNAs (lncRNAs) appear intriguingly complex, adopting many alternative mechanisms of actions and impinging on several basic biological processes of the cell. Deregulations of lncRNAs play a pivotal role in human disease and particularly in cancer. This collection of articles features some of the most relevant studies on lncRNAs published in Cell Death Discovery.