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The role of microRNAs in B-cell development and function

Cellular & Molecular Immunology volume 10, pages 107–112 (2013)Cite this article

Abstract

MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases.

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Acknowledgements

We are grateful to Drs Qi-jing Li and Lili Du for the critical reading of the manuscript. This study was supported by grants from the National Basic Research Program of China (973 program, 2010CB529100) and the National Natural Science Foundation of China (No. 81273288 and No. 81201587).

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Authors and Affiliations

  1. Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

    Jingyi Li & Yongfei Fang

  2. Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, China

    Jingyi Li & Yuzhang Wu

  3. RNA Biology Lab, Biomedical Analysis Center, Third Military Medical University, Chongqing, 400038, China

    Ying Wan

  4. Department of Digestive Diseases, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

    Qing Ji

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  1. Jingyi Li
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Correspondence to Yongfei Fang or Yuzhang Wu.

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Li, J., Wan, Y., Ji, Q. et al. The role of microRNAs in B-cell development and function. Cell Mol Immunol 10, 107–112 (2013). https://doi.org/10.1038/cmi.2012.62

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