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Strongyloides stercoralis hyperinfection after allogeneic stem cell transplantation

Bone Marrow Transplantation volume 43, pages 741–742 (2009)Cite this article

Strongyloides hyperinfection is a potentially fatal syndrome associated with deficient cell-mediated immunity.1, 2 However, despite the severe deficiency of cell-mediated immunity seen after hematopoietic stem cell transplantation (HSCT), this syndrome has rarely been reported, even in endemic areas such as South America.3, 4, 5

A 35-year-old man underwent a peripheral blood cell allograft from his HLA-identical sibling in October 2007 for ALL in third refractory relapse. The conditioning comprised oral busulfan (16 mg/kg) and i.v. melphalan (140 mg/m2). GVHD prophylaxis comprised cyclosporine (3 mg/kg/day). The CD34+ cell dose was 6.58 × 106 per kg. Prophylaxis consisted of fluconazole, acyclovir and cefepime. Engraftment was prompt, and the early post transplant course was uneventful.

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Authors and Affiliations

  1. Hematology-BMT Department, University of São Paulo, São Paulo, Brazil. E-mail: fldulley@usp.br,

    F L Dulley, S Costa, R Cosentino, C Gamba & R Saboya

Authors
  1. F L Dulley
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  2. S Costa
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  3. R Cosentino
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  4. C Gamba
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  5. R Saboya
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Dulley, F., Costa, S., Cosentino, R. et al. Strongyloides stercoralis hyperinfection after allogeneic stem cell transplantation. Bone Marrow Transplant 43, 741–742 (2009). https://doi.org/10.1038/bmt.2008.383

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