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Autografting

Long-term effects of repeated autologous transplantation of bone marrow cells in patients affected by peripheral arterial disease

Bone Marrow Transplantation volume 42, pages 667–672 (2008)Cite this article

Abstract

Long-term effects of autologous mononuclear bone marrow cell transplantation were studied in patients with severe peripheral arterial disease (PAD) and critical limb ischemia. Ten patients with end-stage disease were infused twice with autologous bone marrow cells and they completed the 12-month follow-up study. Substantial improvement of blood flow and increasing capillary densities were seen when compared with a concomitant control group comprising patients who did not enroll in the study. The ankle–brachial index (ABI) and pain-free walking distance improved significantly in treated patients. The improvement was sustained 12 months after treatment. These results confirm that the autologous bone marrow transplantation is an effective therapeutic strategy in critical limb ischemia.

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Acknowledgements

We are grateful to Fondazione Luigi Califano and Fondazione Banco Napoli, which gives us the support needed to perform research. A special thanks to all patients, who believed in us, and to Michela Pietropaolo, Paola Mantovano, Giuseppe Sica and Nino Ceglie, who helped us in coordinating the clinical trial. This paper was written by GC.

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Author notes

  1. G Cobellis and A Silvestroni: These authors contributed equally to this work.

Authors and Affiliations

  1. Dipartimento di Patologia Generale, Cattedra di Patologia Clinica, Seconda Universita' degli Studi di Napoli, Naples, Italy

    G Cobellis, A Silvestroni, C Botti, C Maione & V Sica

  2. Clinica Pineta Grande, Unita' Operativa di Chirurgia Vascolare ed endovascolare, Caserta, Catelvolturno, Italy

    S Lillo, G Sica, V Schiavone & G Brando

  3. AORN Cardarelli, Unita Operativa Complessa di Ematologia, Napoli, Piazzale Cardarelli, Italy

    S Rocco

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  1. G Cobellis
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  2. A Silvestroni
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  3. S Lillo
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  4. G Sica
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  5. C Botti
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  7. V Schiavone
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  8. S Rocco
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  9. G Brando
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Correspondence to G Cobellis.

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Cobellis, G., Silvestroni, A., Lillo, S. et al. Long-term effects of repeated autologous transplantation of bone marrow cells in patients affected by peripheral arterial disease. Bone Marrow Transplant 42, 667–672 (2008). https://doi.org/10.1038/bmt.2008.228

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  • DOI: https://doi.org/10.1038/bmt.2008.228

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