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The Outreach Programme

Haematopoietic stem cell transplantation in children in eastern European countries 1985–2004: development, recent activity and role of the EBMT/ESH Outreach Programme

Bone Marrow Transplantation volume 41, pages S112–S117 (2008)Cite this article

Abstract

The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5%) transplants were performed in paediatric centres, 453 (19.3%) in centres for adults and 402 (17.2%) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45%), whereas 1289 (55%) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3%) out of 1053 auto-transplants, BM in 246 (23.4%) and PB+BM in 52 (4.9%) (missing data in 4, that is, 0.4%). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3%), PB in 416 (32.3%), CB in 23 (1.8%) and BM+PB in 14 (1.1%) (missing data in 9, that is, 0.7%). Among them, 728 (57.4%) obtained HSC from MSD, 322 (25.4%) from UD, 195 (15.4%) from MMFD, 14 (1.1%) from CB family donor and 9 (0.7%) from CB unrelated donor (missing data in 21, that is, 1.6%). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4%), including ALL 376 (29.2%), AML 234 (18.2%), CML 177 (13.8%), MDS 97 (7.5%), NHL 35 (2.7%) and other malignancy 31 (2.4%), while 339 (26.9%) for non-malignant disorders, including SAA 202 (15.7%), immunodeficiencies 61 (4.7%), inborn errors of metabolism 40 (3.1%), Fanconi anaemia 19 (1.5%) and others 17 (1.3%). Out of 1053 recipients of auto-HSCT, 168 (16%) were transplanted for neuroblastoma, 129 (12.2%) for NHL, 124 (11.7%) for AML, 114 (10.8%) for ALL, 109 (10.4%) for Hodgkin's disease, 62 (5.9%) for Ewing's sarcoma, 16 (1.5%) for CNS tumour, 15 (1.4%) for Wilms tumour and 316 (30%) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.

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Acknowledgements

We acknowledge all the participating teams for data reported to the EBMT Registry, and Myriam Labopin, EBMT Statistician from the Acute Leukaemia WP Registry, for data management and statistical evaluation.

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Authors and Affiliations

  1. Department of Paediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, Poland

    J Wachowiak

  2. EBMT Acute Leukemia WP Registry, Paris, France

    M Labopin

  3. Department of Paediatric Haematology and Oncology, IRCCS G Gaslini, Genova, Italy

    M Miano & G Dini

  4. Department of Paediatric Haematology and Oncology, Wroclaw, Poland

    A Chybicka

  5. Department of Paediatric Haematology and Oncology, Prague, Czech Republic

    J Stary

  6. Department of Paediatric Oncology, Brno, Czech Republic

    J Sterba

  7. BMT Unit, St Laszlo Hospital, Budapest, Hungary

    T Masszi

  8. University Hospital Center Rebro, Zagreb, Croatia

    B Labar

  9. Russian's Children's Hospital, Moscow, Russia

    A Maschan

  10. Department of Paediatric Haematology and Oncology, Lublin, Poland

    J R Kowalczyk

  11. Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland

    A Lange

  12. University Department of Haematology and BMT, Katowice, Poland

    J Holowiecki

  13. Department of Paediatrics/BMT Unit, Miskolc, Hungary

    N Kalman

  14. Department of BMT, L Tolstoy Center of Haematology, St Petersburg, Russia

    B V Afanassiev

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  1. J Wachowiak
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on behalf of the EBMT Paediatric Working Party

Corresponding author

Correspondence to J Wachowiak.

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Conflict of interest

None of the authors declared any financial interests.

Appendix

Appendix

List of eastern European transplant centres reporting paediatric HSCTs to the EBMT Registry. The total number of transplantations are listed first, followed by the number of allografts/autografts.

Department of Children's Hematology and Oncology, CIC 817, Medical Univeristy, Wroclaw, PL (411; 230/181); Department of Paediatric Hematology and Oncology, CIC 656, University Hospital Motol, Prague, CZ (300; 218/82); Department of Paediatric Oncology, CIC 597, University Hospital, Brno, CZ, (191; 1/190); Department of Pediatric Oncology, Hematology and Transplantology, CIC 641, University of Medical Sciences, Poznan, PL, (160; 150/10); Szent Laszlo Hospital, CIC 739,Budapest, H, (156; 112/44); University Hospital Center Rebro, CIC 302, Zagreb, HR, (129; 58/71); Department of Bone Marrow Translant Research Institute for Pediatric Hematology, CIC 694 Russian's Children's Hospital, Moscow, RUS, (108; 77/31); Lower Silesian Centre for Cellular Transplantation with Marrow Donor Registry, CIC 538, Wroclaw, PL (103; 89/14); Department of Hematology and BMT, CIC 677, Silesian Medical Academy, Katowice, PL (99; 51/48); Department of Pediatrics/BMT Unit GYEK, CIC 599, Postgraduate Medical School, Miskolc, H (93; 27/66); Children's University Hospital Hematology/Oncology, CIC 678, Lublin, PL (92; 40/52); Department of BMT Centre of Hematology, CIC 725, Pavlov Medical University, St Petersburg, RUS (78; 36/42); BMT Unit II Children's Clinic, CIC 684, Pediatric University Teaching Hospital, Bratislava, SK (62; 30/32); Specialized Children's Oncohematology Hospital, CIC 346, Sofia, BG (45; 11/34); Department of Hematology, CIC 730, University of Medical Science, Poznan, PL (39; 14/25); Clinic of Haematology, CIC 582, Military Medical Academy, Belgrade, BIH (36; 30/6); Department of Hematology, CIC 640, University Medical Center, Ljubljana, SLO (35; 21/14); Clinic of Hematology/Oncology, CIC 746, Tartu University Hospital, Tartu, EST (26; 4/22); Department Hematology/Stem Cell Transplant, CIC 504, National Medical Centre, Budapest, H (20; 19/1); Oncology/Hematology BMT, CIC 508, Vilnius University Children's Hospital, Vilnius, LT (19; 6/13); Department of Transplantation Jagiellonian University Medical College, CIC 507, Polish-American Institute of Paediatrics, Cracow-PL, (18; 0/18); Bellorussian Centre for Paediatric Hematology/Oncology, CIC 591, Minsk, BY (17; 17/0); Hospital No 9, CIC 801, Minsk, BY (16; 7/9); Institute of Clinical Immunology, CIC 376, Novosibirsk, RUS (15; 1/14); Research Institute of Hematology, CIC 724, St. Petersburg, RUS (15; 6/9); Pediatric Hematology/Oncology, CIC 764, University Hospital Coll. Med. UMK, Bydgoszcz, PL (13; 3/10); Department of Hematology/Oncology, CIC 718, Charles University Hospital, Pilsen, CZ (10; 8/2); Clinic of Hematology/Transplantology, CIC 610, University Hospital, Bratislava, SK (7; 4/3); Department BMT Unit, CIC 816, Military Medical Academy, Warsaw, PL (6; 5/1); Centre of Hematology/BMT, CIC 296, Fundeni University Institute, Bucharest, RO (5; 3/2); Department of Haematology, CIC 799, Medical University, Gdansk, PL (5; 3/2); IIIrd Paediatric Clinic Hematooncology, CIC 174, University of Medicine and Pharmacy, Timisoara, RO (3; 0/3); Department of Hematology/Oncology, CIC 954, Central Clinical Hospital Med. Univ., Warsaw, PL (3; 2/1); Department of Hematology, CIC 333, Roosevelt Hospital, Banskà Bystrica-SK (2; 0/2); Department of Haematology, CIC 553, Jagiellonian University, Krakow, PL (2; 2/0); Department Hematooncology Intensive Care, CIC 800, M Sklodowska-Curie Memorial Cancer Centre Warsaw, PL (2; 2/0); Department BMT, CIC 370, Clinical Center for Advanced Medical Technologies, St Petersburg, RUS (1; 0/1).

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Wachowiak, J., Labopin, M., Miano, M. et al. Haematopoietic stem cell transplantation in children in eastern European countries 1985–2004: development, recent activity and role of the EBMT/ESH Outreach Programme. Bone Marrow Transplant 41 (Suppl 2), S112–S117 (2008). https://doi.org/10.1038/bmt.2008.68

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