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Significant increase in end-stage renal disease after hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 39, pages 571–572 (2007)Cite this article

Chronic renal failure (CRF) after hematopoietic stem cell transplantation (HCT) is a well-acknowledged complication of HCT.1, 2 Its most severe consequence is end-stage renal disease (ESRD), which requires dialysis or kidney transplantation to sustain life. We report herein the very high age-adjusted risk of ESRD after HCT.

Acute renal failure, occurring usually within the first 30 days after HCT, is associated with neutropenic sepsis and use of nephrotoxins.3 CRF has been linked to both chemo-irradiation conditioning and chronic graft-versus-host disease.4, 5 A very recent report documented its occurrence in 23% of long-term HCT survivors.6 In this study, CRF was defined as chronic kidney disease, with a calculated glomerular filtration rate (GFR) of <60 ml/min (normal is 80–120). This report did not provide information on the exact level of GFR in their cases. Reduction in GFR to lower levels may be more significant than only modest reductions in GFR.

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  1. Departments of Medicine and Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    E P Cohen, W R Drobyski & J E Moulder

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  1. E P Cohen
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  2. W R Drobyski
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  3. J E Moulder
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Correspondence to E P Cohen.

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Cohen, E., Drobyski, W. & Moulder, J. Significant increase in end-stage renal disease after hematopoietic stem cell transplantation. Bone Marrow Transplant 39, 571–572 (2007). https://doi.org/10.1038/sj.bmt.1705643

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