Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Nephrotic syndrome following allogeneic stem cell transplantation associated with increased production of TNF-alpha and interferon-gamma by donor T cells

Bone Marrow Transplantation volume 32, pages 447–450 (2003)Cite this article

Summary:

Tumor necrosis factor-alpha (TNF-α) has been implicated in the immunological complications of stem cell transplantation (SCT) including graft-versus-host disease (GVHD). In this report of a patient undergoing allogeneic SCT for AML, serial cytokine measurements by real-time PCR revealed increased production of interferon-gamma (IFN-γ) and TNF-α, but not interleukin (IL)-4 in purified T cells following withdrawal of immunosuppression. Cytokine changes were contemporaneous with the onset of nephrotic syndrome (NS), a rare manifestation of GVHD. These findings indicate that serial cytokine monitoring may allow for the prediction of GVHD during immunosuppression withdrawal and lend further insight into the pathogenesis of NS.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Sato N, Kishi K, Yagisawa K et al. Nephrotic syndrome in a bone marrow transplant recipient with chronic graft-versus-host disease. Bone Marrow Transplant 1995; 16: 303–305.

    CAS  PubMed  Google Scholar 

  2. Oliveira JS, Bahia D, Franco M et al. Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal. Bone Marrow Transplant 1999; 23: 99–101.

    Article  CAS  Google Scholar 

  3. Lama G, Luongo I, Tirino G et al. T-lymphocyte populations and cytokines in childhood nephrotic syndrome. Am J Kidney Dis 2002; 39: 958–965.

    Article  CAS  Google Scholar 

  4. Kim YS, Zheng S, Yang SH et al. Differential expression of various cytokine and chemokine genes between proliferative and non-proliferative glomerulonephritides. Clin Nephrol 2001; 56: 199–206.

    CAS  PubMed  Google Scholar 

  5. Schmaltz C, Alpdogan O, Muriglan SJ et al. Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation. Blood 2002. Pre-published online November 7. Vol 101: pp 2440–2445.

    Article  Google Scholar 

  6. Cooke KR, Hill GR, Crawford JM et al. Tumor necrosis factor-alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. J Clin Invest 1998; 102: 1882–1891.

    Article  CAS  Google Scholar 

  7. Burnett A, Goldstone AH, Milligan DW et al. Medical Research Council Acute Myeloid Leukaemia 12 Protocol. Clinical Trials Service Unit, Oxford, UK.

  8. Ruutu T, Volin L, Parkkali T et al. Cyclosporine, methotrexate, and methylprednisolone compared with cyclosporine and methotrexate for the prevention of graft-versus-host disease in bone marrow transplantation from HLA-identical sibling donor: a prospective randomized study. Blood 2000; 96: 2391–2398.

    CAS  Google Scholar 

  9. Teshima T, Ordemann R, Reddy P et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med 2002; 8: 575–581.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand

    J Seconi, V Watt & D S Ritchie

  2. Wellington Cancer Centre, Capital and Coast Health Ltd., Wellington, New Zealand

    D S Ritchie

Authors
  1. J Seconi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V Watt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D S Ritchie
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seconi, J., Watt, V. & Ritchie, D. Nephrotic syndrome following allogeneic stem cell transplantation associated with increased production of TNF-alpha and interferon-gamma by donor T cells. Bone Marrow Transplant 32, 447–450 (2003). https://doi.org/10.1038/sj.bmt.1704151

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704151

Keywords

This article is cited by

Search

Advanced search

Quick links