Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Autologous peripheral blood stem cell transplantation for peripheral neuropathy secondary to monoclonal gammopathy of unknown significance

Bone Marrow Transplantation volume 30, pages 53–56 (2002)Cite this article

Abstract

A 40-year-old patient presented with rapidly progressing peripheral neuropathy secondary to monoclonal gammopathy of unknown significance (MGUS). He became severely debilitated, being wheelchair-bound, despite treatment with chemotherapy, intravenous immunoglobulin and plasma exchange. He was subsequently treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT). He has made remarkable recovery at 12 months post transplantation. We propose that high-dose chemotherapy and autologous PBSC transplantation may have a role in the treatment of severe, progressive and treatment-resistant MGUS-related peripheral neuropathy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Bosch EP, Smith BE . Disorders of peripheral nerves. In: Bradley WG, Daroff RB, Fenichel GM (eds) Neurology in Clinical Practice, 3rd edn Butterworth & Heinemann: Boston 2000 2092 2093

    Google Scholar 

  2. Mariette X, Chastang C, Clavelon P et al. A randomised clinical trial comparing interferon-alpha and intravenous immunoglobulin in polyneuropathy associated with monoclonal IgM J Neurol Neurosurg Psychiat 1997 62: 310 318

    Article  Google Scholar 

  3. Cook D, Dalakas M, Galdi A et al. High dose intravenous immunoglobulin in the treatment of demyelinating neuropathy associated with monoclonal gammopathy Neurology 1999 40: 212 214

    Article  Google Scholar 

  4. Leger JM, Ben Younes-Chennoufi A, Chassande B et al. Treatment with human immunoglobulin of multifocal neuropathy and polyneuropathy associated with monoclonal gamopathy J Neurol Neursurg Psychiat 1995 57: (Suppl.) 46 49

    Article  Google Scholar 

  5. Notermans NC, Lokhorst HM, Franssen H et al. Intermittent cyclophosphamide and prednisone treatment of polyneuropathy associated with monoclonal gammopathy of undetermined significance Neurology 1996 47: 1227 1233

    Article  CAS  Google Scholar 

  6. Kyle RA . ‘Benign’ monoclonal gammopathy – after 20 to 30 years of follow up Mayo Clin Proc 1993 68: 26 36

    Article  CAS  Google Scholar 

  7. Latov N, Sherman W, Nemni R et al. Plasma cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral nerve myelin New Engl J Med 1981 303: 618 621

    Article  Google Scholar 

  8. Frayne J, Stark R . Peripheral neuropathy with gammopathy responding to plasmapheresis Clin Exp Neurol 1985 21: 195 200

    CAS  PubMed  Google Scholar 

  9. Gosselin S, Kyle RA, Dyck PJ . Neuropathy associated with monoclonal gammopathy of undetermined significance Ann Neurol 1991 30: 54 61

    Article  CAS  Google Scholar 

  10. Dyck PJ, Low PA, Windebank AJ et al. Plasma exchange in polyneuropathy associated with monogammopathy of undetermined significance New Engl J Med 1991 21: 1482 1488

    Article  Google Scholar 

  11. Latov N, Sherman WH . Therapy of neuropathy associated with anti-MAG IgM monoclonal gammopathy with Rituxan Neurology 1999 52: (Suppl. 2) A551

    Article  Google Scholar 

  12. Hogan WJ, Lacy MQ, Wiseman GA et al. Successful treatment of POEMS syndrome with autologous hemapoietic progenitor cell transplantation Bone Marrow Transplant 2001 28: 305 309

    Article  CAS  Google Scholar 

  13. Rudnicki SA, Harik SI, Dhodapkar M et al. Nervous system dysfunction in Waoldenstrom's macroglobulinemia: response tp treatment Neurology 1998 51: 1210 1213

    Article  CAS  Google Scholar 

  14. Grimes DJ, Staples CI, Cobcroft RG et al. Complete remission of paraproteinaemia and neuopathy following iatrogenic oral melphalan overdose Br J Haematol 1993 83: 675 677

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bone Marrow Transplantation Programme, Alfred Hospital, Melbourne, Victoria, Australia

    YC Lee, N Came & A Schwarer

  2. Department of Neuroscience, Alfred Hospital, Melbourne, Victoria, Australia

    B Day

Authors
  1. YC Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N Came
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Schwarer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B Day
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, Y., Came, N., Schwarer, A. et al. Autologous peripheral blood stem cell transplantation for peripheral neuropathy secondary to monoclonal gammopathy of unknown significance. Bone Marrow Transplant 30, 53–56 (2002). https://doi.org/10.1038/sj.bmt.1703582

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703582

Keywords

This article is cited by

Search

Advanced search

Quick links