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Morphologic changes leading to bronchiolitis obliterans in a patient with delayed non-infectious lung disease after allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 28, pages 1167–1170 (2001)Cite this article

Abstract

A 37-year-old man developed delayed non-infectious lung disease after undergoing bone marrow transplantation (BMT) for acute myeloid leukaemia. Over a 15-month period, the progression of morphologic changes from cellular interstitial pneumonia to bronchiolitis obliterans organizing pneumonia and cicatricial bronchiolitis obliterans was documented. Pulmonary function tests, high-resolution CT, bronchoalveolar lavage, lung biopsy and extensive microbiological studies were used as diagnostic tools either at onset and during the follow-up. This represents the first reported case in which a model – supported by longitudinal biopsy results – for the evolution of histologic lesions toward bronchiolitis obliterans after BMT is suggested; therapeutic implications are discussed.

Bone Marrow Transplantation (2001) 28, 1167–1170.

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Authors and Affiliations

  1. Department of Thoracic Diseases, Maggiore Hospital, Bologna, Italy

    R Trisolini, M Boaron & V Poletti

  2. Department of Pathology, Maggiore Hospital, Bologna, Italy

    A Cancellieri

  3. Institute of Hematology and Clinical Oncology ‘L & A Seragnoli’, University Hospital S Orsola, Bologna, Italy

    G Bandini & M Stanzani

  4. Department of Pathology, University Hospital Borgo Roma, Verona, Italy

    M Chilosi

Authors
  1. R Trisolini
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  2. G Bandini
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  3. M Stanzani
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  4. M Chilosi
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  5. A Cancellieri
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  6. M Boaron
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  7. V Poletti
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Trisolini, R., Bandini, G., Stanzani, M. et al. Morphologic changes leading to bronchiolitis obliterans in a patient with delayed non-infectious lung disease after allogeneic bone marrow transplantation. Bone Marrow Transplant 28, 1167–1170 (2001). https://doi.org/10.1038/sj.bmt.1703303

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  • DOI: https://doi.org/10.1038/sj.bmt.1703303

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