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Skin involvement as the first manifestation of systemic aspergillosis in patients after allogeneic hematopoietic cell transplantation

Bone Marrow Transplantation volume 27, pages 753–755 (2001)Cite this article

Abstract

Skin involvement due to a systemic infection with Aspergillus species in the course of allogeneic hematopoietic cell transplantation is extremely rare. We report the clinical course of two patients with hematologic malignancies who underwent allogeneic hematopoietic cell transplantation (HCT) and developed disseminated skin involvement as the first clinical symptom of a proven systemic Aspergillus infection. Bone Marrow Transplantation (2001) 27, 753–755.

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References

  1. Beyer J, Schwartz S, Heinemann V et al. Strategies in prevention of invasive pulmonary aspergillosis in immunosuppressed or neutropenic patients Antimicrobial Agents Chemother 1994 38: 911–917

    Article  CAS  Google Scholar 

  2. Wingard JR, Beals SU, Santos GW et al. Aspergillus infection in bone marrow transplant recipients Bone Marrow Transplant 1987 2: 175–181

    CAS  PubMed  Google Scholar 

  3. Walsh TJ, Dixon DM . Nosocomial aspergillosis: environmental microbiology, hospital epidemiology, diagnosis and treatment Eur J Epidemiol 1989 5: 131–142

    Article  CAS  PubMed  Google Scholar 

  4. Allo MD, Miller J, Townsend T et al. Primary cutaneous aspergillosis associated with Hickman intravenous catheters New Engl J Med 1987 317: 1105–1108

    Article  CAS  PubMed  Google Scholar 

  5. Saugier-Veber P, Devergie A, Sulahian A et al. Epidemiology and diagnosis of invasive pulmonary aspergillosis in bone marrow transplant patients: results of a 5 year retrospective study Bone Marrow Transplant 1993 12: 121–124

    CAS  PubMed  Google Scholar 

  6. Viollier AF, Peterson DE, De Jongh CA et al. Aspergillus sinusitis in cancer patients Cancer 1986 58: 366–371

    Article  CAS  PubMed  Google Scholar 

  7. Talbot GH, Huang A, Provencher M . Invasive aspergillus rhinosinusititis in patients with acute leukemia Rev Infect Dis 1991 13: 219–232

    Article  CAS  PubMed  Google Scholar 

  8. Chakrabarti A, Gupta V, Biswas G et al. Primary cutaneous aspergillosis: our experience in 10 years J Infect 1998 37: 24–27

    Article  CAS  PubMed  Google Scholar 

  9. Khardori N, Hayat S, Rolston K, Bodey GP . Cutaneous Rhizopus and Aspergillus infection in five patients with cancer Arch Dermatol 1989 125: 952–956

    Article  CAS  PubMed  Google Scholar 

  10. Lucas GM, Tucker P, Merz WG . Primary cutaneous Aspergillus nidulans infection associated with a Hickman catheter in a patient with neutropenia Clin Infect Dis 1999 29: 1594–1596

    Article  CAS  PubMed  Google Scholar 

  11. van Burik JA, Colven R, Spach DH . Cutaneous aspergillosis J Clin Microbiol 1998 36: 3115–3121

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Findlay G, Roux H, Simson I . Skin manifestations in disseminated aspergillosis Br J Dermatol 1971 85: (Suppl. 7) 94–97

    Article  Google Scholar 

  13. Vedder JS, Schorr WF . Primary disseminated pulmonary aspergillosis with metastatic skin nodules JAMA 1969 209: 1191–1195

    Article  CAS  PubMed  Google Scholar 

  14. Barnes RA . Immunological diagnosis of fungal infection in the immunocompromised host Rev Med Mikcrobiol 1990 1: 58–65

    Google Scholar 

  15. Williamson EC, Leeming JP, Palmer HM et al. Diagnosis of invasive aspergillosis in bone marrow transplant recipients by polymerase chain reaction Br J Haematol 2000 108: 132–139

    Article  CAS  PubMed  Google Scholar 

  16. Hebart H, Loffler J, Meisner C et al. Early detection of aspergillus infection after allogeneic stem cell transplantation by polymerase chain reaction screening J Infect Dis 2000 181: 1713–1719

    Article  CAS  PubMed  Google Scholar 

  17. Heussel CP, Kauczor HU, Heussel GE et al. Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography J Clin Oncol 1999 17: 796–805

    Article  CAS  PubMed  Google Scholar 

  18. Siegert W, Henze G, Wagner J et al. Invasive Trichosporon Cutaneum infection in a patient with relapsed acute myeloid leukemia undergoing bone marrow transplantation Transplantation 1988 46: 151–153

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany

    C Schimmelpfennig, R Naumann, R Ordemann, M Bornhäuser & G Ehninger

  2. Medizinische Klinik und Poliklinik mit Schwerpunkt Hämatologie und Onkologie, Charité, Humboldt Universität Berlin, Berlin, Germany

    H Baurmann, J Beyer & W Siegert

  3. Klinik für Dermatologie, Venerologie und Allergologie mit Asthmapoliklinik, Charite, Berlin, Germany

    T Zuberbier

Authors
  1. C Schimmelpfennig
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  2. R Naumann
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  3. T Zuberbier
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  4. R Ordemann
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  5. H Baurmann
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  6. J Beyer
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  7. W Siegert
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  8. M Bornhäuser
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  9. G Ehninger
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Schimmelpfennig, C., Naumann, R., Zuberbier, T. et al. Skin involvement as the first manifestation of systemic aspergillosis in patients after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 27, 753–755 (2001). https://doi.org/10.1038/sj.bmt.1702835

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  • DOI: https://doi.org/10.1038/sj.bmt.1702835

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