Abstract
Follicular lymphoma is a B cell malignancy prone to transformation into a large cell diffuse histology. This progression may be multi-clonal as determined by IgH rearrangement. Similar multi-clonal occurrences have been described in immunocompromised patients. However, the lymphoma cells remain predominantly of B cell type. Rarely, composite lymphomas with diffuse T cell histology have been reported arising from follicular lymphoma. The development of T cell leukaemia in a patient with a pre-existing B cell malignancy is an extremely rare event. The occurrence of T cell acute lymphoblastic leukaemia (T-ALL) following follicular lymphoma (FL) has not previously been reported. We report a case of Philadelphia positive (Ph+) T cell ALL developing in a patient who previously had FL which may give some insight into the cell of origin and the defects responsible for malignant transformation of the lymphocytes. Bone Marrow Transplantation (2000) 26, 1113–1115.
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References
Salles G, Coiffier B . Histologic transformation in follicular lymphoma Ann Oncol 1998 9: 803–805
Cotter FE, Hall PA, Young BD, Lister TA . Simultaneous presentation of T-and B-cell malignant lymphoma with Bcl-2 gene involvement Blood 1989 73: 1387–1388 (letter)
Westbrook CA, Hooberman AL, Spino C et al. Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukaemia: a Cancer and Leukaemia Group B study (8762) Blood 1992 80: 2983–2990
Thirman MJ, Larson RA . Therapy-related myeloid leukaemia Hematol Oncol Clin N Am 1996 10: 293–319
Reardon DA, Hanson CA, Roth MS, Castle VP . Lineage switch in Philadelphia chromosome positive acute lymphoblastic leukaemia Cancer 1994 73: 1526–1532
Tatsumi T, Shimazaki C, Araki S et al. Philadelphia chromosome positive acute lymphoblastic leukaemia after therapy for Langerhans cell histiocytosis Am J Hematol 1997 54: 88 (letter)
Bentz M, Werner CA, Dohner H et al. High incidence of chromosomal imbalances and gene amplification in the classical folicular variant of follicle center lymphoma Blood 1996 88: 1437–1444
Johansson B, Mertens F, Mitelman F . Cytogenetic evolution patterns in non-Hodgkin's lymphomas Blood 1995 86: 3905–3914
Kramer MHH, Raghoebier S, Beverstock GC et al. De novo B cell leukaemia with translocation t(14;18): an entity with a poor prognosis Leukemia 1991 5: 473–478
McDonnell TJ, Korsmeyer SJ . Progression from lymphoid hyperplasia to high grade malignant lymphoma in mice transgenic for the t(14;18) Nature 1991 349: 254–256
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Auer, R., Oates, J., Reid, S. et al. Philadelphia-positive T-ALL in a patient with follicular lymphoma. Bone Marrow Transplant 26, 1113–1115 (2000). https://doi.org/10.1038/sj.bmt.1702670
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DOI: https://doi.org/10.1038/sj.bmt.1702670