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Work is ongoing to recover UK clinical research capacity and capabililty post COVID-19 pandemic (https://sites.google.com/nihr.ac.uk/thefutureofukclinicalresearch/home), but many of the barriers investigators faced pre-pandemic persist. Taking a more patient-centred approach to reform may help apply lessons learned during the pandemic and facilitate ‘building back better’.
In an attempt to overcome resistance to immune checkpoint inhibitors (ICI), an ever-increasing number of trials are exploring combination treatment approaches. Outcomes of a novel ICI doublet presented by Desai and colleagues are discussed along with emerging novel strategies and a view to future ongoing rational trial design maximising patient benefit.
