Short Communication
British Journal of Cancer (2008) 99, 1534–1538. doi:10.1038/sj.bjc.6604687 www.bjcancer.com
Published online 23 September 2008
Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer
H Jernström1,2, M Henningson1, U Johansson1 and H Olsson3
- 1Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden
- 2Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden
- 3Department of Oncology and Cancer Epidemiology, Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden
Correspondence: Dr H Jernström, E-mail: helena.jernstrom@med.lu.se
Received 10 July 2008; Revised 1 September 2008; Accepted 1 September 2008; Published online 23 September 2008.
Abstract
As breast volume may be associated with heart cancer risk, we studied the relationship between breast volume, CYP1A2*1F and coffee intake. Among healthy premenopausal non-hormone users, 3+ cups per day was associated with lower volume only in C-allele carriers (Pinteraction=0.02), which is consistent with reports that coffee protects only C-allele carriers against breast cancer.
Keywords:
breast cancer, CYPIA2, coffee, breast volume, BRCA1/2, oral contraceptive
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