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British Journal of Cancer (2008) 98, 660-663.
doi:10.1038/sj.bjc.6604183 www.bjcancer.com Published online 5 February 2008
Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk
W C Strohsnitter1, T M Savarese2,
, H P Low3, D P Chelmow1, P Lagiou4, M Lambe5, K Edmiston6, Q Liu2, I Baik2, K L Noller1, H-O Adami5,7, D Trichopoulos7 and C-C Hsieh2,5,71Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA, USA
2Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA, USA
3Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
4Department of Hygiene and Epidemiology, School of Medicine, Athens University, Athens, Greece
5Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
6Division of Hematology/Oncology, Department of Medicine, UMass Medical School and UMass Memorial Health Care, Worcester, MA, USA
7Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Correspondence to: Dr C-C Hsieh, Division of Biostatistics and Epidemiology, Department of Cancer Biology, UMass Cancer Center, University of Massachusetts Medical School, Worcester, MA, USA. E-mail: chung.hsieh@umassmed.edu
Deceased.Received 29 October 2007; revised 30 November 2007; accepted 7 December 2007; published online 5 February 2008
We examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38- cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns with
3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk.Keywords: birth weight; cancer risk; prenatal exposure; stem cell
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