Abstract
We searched for mutations of the p53 gene in 25 phaeochromocytomas using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of the entire conserved region of the gene, encompassing exons 4-8; expression of the p53 protein was assessed by immunohistochemistry. No mutations were found, while a polymorphism in codon 72 was observed. Immunohistochemistry revealed nuclear p53 overexpression in one tumour sample. We conclude that mutations of the 'hotspot' region of the p53 gene do not seem to play a role in the pathogenesis of phaeochromocytoma.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dahia, P., Aguiar, R., Tsanaclis, A. et al. Molecular and immunohistochemical analysis of P53 in phaeochromocytoma. Br J Cancer 72, 1211–1213 (1995). https://doi.org/10.1038/bjc.1995.487
Issue Date:
DOI: https://doi.org/10.1038/bjc.1995.487
This article is cited by
-
Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas
Modern Pathology (2008)
-
Concurrent pheochromocytoma, paraganglioma, papillary thyroid carcinoma, and desmoid tumor: A case report with analyses at the molecular level
Endocrine Pathology (1998)
-
P53 protein and its messenger ribonucleic acid in human adrenal tumors
Journal of Endocrinological Investigation (1998)