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Ovarian failure following abdominal irradiation in childhood

British Journal of Cancer volume 33, pages 655–658 (1976)Cite this article

Abstract

Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16.

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Authors
  1. S M Shalet
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  2. C G Beardwell
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  3. P H MORRIS Jones
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  4. D Pearson
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  5. D H Orrell
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Shalet, S., Beardwell, C., Jones, P. et al. Ovarian failure following abdominal irradiation in childhood. Br J Cancer 33, 655–658 (1976). https://doi.org/10.1038/bjc.1976.103

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  • DOI: https://doi.org/10.1038/bjc.1976.103

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