Short Communication

BJC Open article

British Journal of Cancer (2009) 100, 1603–1607. doi:10.1038/sj.bjc.6605058 www.bjcancer.com
Published online 28 April 2009

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

J Nilsson1,2, J Skog3, A Nordstrand1, V Baranov4, L Mincheva-Nilsson4, X O Breakefield3 and A Widmark1

  1. 1Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden
  2. 2Neuro-oncology Research Group, Cancer Center Amsterdam, Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands
  3. 3Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, MA, USA
  4. 4Department of Clinical Immunology, Umeå University, Umea, Sweden

Correspondence: Dr J Nilsson, VU University Medical Center, Amsterdam, Department of Neurosurgery, Neuro-oncology Research Group, Cancer Center Amsterdam, room 3. 60, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. E-mail: j.nilsson@vumc.nl

Received 7 October 2008; Revised 4 March 2009; Accepted 30 March 2009
Advance online publication 28 April 2009

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Abstract

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.

Keywords:

prostate cancer; prostasomes; tumour exosomes; biomarkers

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