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Optimizing the treatment of hypothyroidism

Nature Reviews Endocrinology (2024)Cite this article

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Daily levothyroxine (LT4) is the standard of care for the treatment of hypothyroidism; however, a small number of patients experience residual symptoms of hypothyroidism. Guidelines indicate that a trial with LT4 and liothyronine (LT3) could be attempted once other conditions have been addressed or excluded. Even so, currently, treatment of hypothyroidism can still be suboptimal.

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Authors and Affiliations

  1. Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago School of Medicine, Chicago, IL, USA

    Antonio C. Bianco

  2. Thyroid Research Group, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK

    Peter N. Taylor

Authors
  1. Antonio C. Bianco
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  2. Peter N. Taylor
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Correspondence to Antonio C. Bianco.

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Competing interests

A.C.B. is a consultant for AbbVie, Acella, Synthonics. P.N.T. declares no competing interests.

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Bianco, A.C., Taylor, P.N. Optimizing the treatment of hypothyroidism. Nat Rev Endocrinol (2024). https://doi.org/10.1038/s41574-024-00989-7

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  • DOI: https://doi.org/10.1038/s41574-024-00989-7

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