Dietary fibre deprivation in mice increases the abundance of gut microbial mucin-degrading species, leads to barrier dysfunction and increases local type 2 inflammation. In a tractable human microbiota mouse model, the presence of Akkermansia muciniphila results in increased anti-commensal IgE and type 2 immune responses, worsening food allergy symptoms following sensitization.
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References
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This is a summary of: Parrish, A. et al. Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01464-1 (2023).
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A mucin-foraging bacterium modulates breakdown of oral tolerance. Nat Microbiol 8, 1766–1767 (2023). https://doi.org/10.1038/s41564-023-01480-1
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DOI: https://doi.org/10.1038/s41564-023-01480-1
