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Greasing the receptor

Components of the sphingolipid biosynthetic pathway induce a favourable conformation in the proteinaceous murine norovirus receptor (CD300lf) that facilitates virus entry.

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Fig. 1: Ceramide biosynthesis impacts biophysical properties of ceramide-enriched membrane platforms and presentation of CD300lf in receptor-competent conformations.

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Correspondence to Benhur Lee.

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Lee, B. Greasing the receptor. Nat Microbiol 3, 1082–1083 (2018). https://doi.org/10.1038/s41564-018-0251-2

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