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Examining psychedelic drug action

Nature Chemistry volume 16, page 142 (2024)Cite this article

Dewran Kocak and Bryan Roth discuss a psychedelic — 5-MeO-DMT — and what we might learn from its properties.

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References

  1. Ross, S. et al. J. Psychopharmacol. 30, 1165–1180 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Griffiths, R. R. et al. J. Psychopharmacol. 30, 1181–1197 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. McClure-Begley, T. D. & Roth, B. L. Nat. Rev. Drug Discov. 21, 463–473 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Gribkoff, V. K. & Kaczmarek, L. K. Neuropharmacology 120, 11 (2017).

    Article  CAS  PubMed  Google Scholar 

  5. Willins, D., Deutch, A. & Roth, B. Synapse 27, 79-82 (1997).

  6. Al-Imam, A., Motyka, M. A., Hoffmann, B., Magowska, A. & Michalak, M. Pharmaceuticals 16, 831 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Reckweg, J. et al. Front. Pharmacol. 12, 760671 (2021).

    Article  PubMed Central  Google Scholar 

  8. Phillips, C. A. Copeia 2, 391–393 (2014).

    Google Scholar 

  9. Erspamer, V., Vitali, T., Roseghini, M. & Cei, J. M. Biochem. Pharmacol. 16, 1149–1164 (1967).

    Article  CAS  PubMed  Google Scholar 

  10. Hesselgrave, N., Troppoli, T. A., Wulff, A. B., Cole, A. B. & Thompson, S. M. Proc. Natl Acad. Sci. USA 118, e2022489118 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Moliner, R. et al. Nat. Neurosci. 26, 1032–1041 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kaplan, A. L. et al. Nature 610, 582–591 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Author notes

  1. Twitter/X: @dewrankocak; @zenbrainest

Authors and Affiliations

  1. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    D. Dewran Kocak & Bryan L. Roth

Authors
  1. D. Dewran Kocak
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  2. Bryan L. Roth
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Corresponding authors

Correspondence to D. Dewran Kocak or Bryan L. Roth.

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Competing interests

B.L.R. serves on the Scientific Advisory Boards of Onsero Therapeutics, Escient Pharmaceuticals, Epiodyne Inc. D.D.K. declares no competing interests.

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Kocak, D.D., Roth, B.L. Examining psychedelic drug action. Nat. Chem. 16, 142 (2024). https://doi.org/10.1038/s41557-023-01412-w

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