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CELL-PENETRATING PEPTIDES

Chemical passports to cross biological borders

Nature Chemistry volume 13, pages 517–519 (2021)Cite this article

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The cell membrane acts as a border that restricts uptake of extracellular proteins. Now, peptide chemists have developed two new approaches for transporting functional and biologically relevant proteins across the cellular border by anchoring cyclic polyarginine peptides on the cell membrane.

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Fig. 1: New approaches for increasing the cellular entry kinetics of cell-penetrating peptides and cargo molecules by enhancing peptide–membrane interaction.

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Authors and Affiliations

  1. Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan

    Jan Vincent V. Arafiles & Shiroh Futaki

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  1. Jan Vincent V. Arafiles
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  2. Shiroh Futaki
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Correspondence to Shiroh Futaki.

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The authors declare no competing interests.

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Arafiles, J.V.V., Futaki, S. Chemical passports to cross biological borders. Nat. Chem. 13, 517–519 (2021). https://doi.org/10.1038/s41557-021-00694-2

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