Biological receptors distinguish between S- and R-enantiomers and these subtle differences in chirality can lead to vastly different protein affinities. Now, a proteomics approach has been developed that capitalizes on chirality to map enantiomeric probe pairs and provides a rapid and global view of protein ligandability within the cell.
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Amako, Y., Woo, C.M. A chiral trick to map protein ligandability. Nat. Chem. 11, 1080–1082 (2019). https://doi.org/10.1038/s41557-019-0380-0
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DOI: https://doi.org/10.1038/s41557-019-0380-0
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