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Hypertension facilitates age-related diseases. ~ Is hypertension associated with a wide variety of diseases?~

Hypertension Research volume 47, pages 1246–1259 (2024)Cite this article

Abstract

Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction. Therefore, we hypothesized that hypertension is associated with all age-related vascular diseases, and attempted to review the relationship between hypertension and diseases for which a relationship has not been previously well reported. Following our review, we hope that a collaborative effort to unravel age-related diseases from the perspective of hypertension will be undertaken together with experts in various specialties regarding the relationship of hypertension to all pathological conditions.

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Authors and Affiliations

  1. Department of Pharmacology, Ehime University Graduate School of Medicine, Matsuyama, Japan

    Masaki Mogi, Yasuhito Ikegawa & Shunsuke Haga

  2. Department of Ophthalmology, Ehime University Graduate School of Medicine, Matsuyama, Japan

    Yasuhito Ikegawa

  3. Department of Urology, Ehime University Graduate School of Medicine, Matsuyama, Japan

    Shunsuke Haga

  4. Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan

    Satoshi Hoshide & Kazuomi Kario

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  1. Masaki Mogi
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Correspondence to Masaki Mogi.

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Mogi, M., Ikegawa, Y., Haga, S. et al. Hypertension facilitates age-related diseases. ~ Is hypertension associated with a wide variety of diseases?~. Hypertens Res 47, 1246–1259 (2024). https://doi.org/10.1038/s41440-024-01642-6

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