Abstract
Clinical question
To evaluate the efficacy of silver diamine fluoride (SDF) in arresting dental caries in cavitated caries lesions in primary molars.
Data sources
A systematic search was carried out in PubMed, Scopus, and Embase. Furthermore, cross-referencing was performed using the references lists of full-text articles and grey literature was also retrieved for eligible studies. Two independent reviewers were responsible for study selection and data extraction.
Study selection
Randomized and non-randomized clinical studies that evaluated the caries arrest rate of SDF compared to no treatment or any other type of non-invasive or minimally-invasive treatment were included. Only publications in the English, Italian and French language and with a minimum follow-up of 6 months were considered for study eligibility.
Data extraction and synthesis
The characteristics of the included studies—age, sex, type of study, sample size, caries at baseline, setting, operator, blinding, intervention, outcomes and assessment of any confounders—were extracted from the included papers. The quality assessment was carried out using the Cochrane risk of bias tool. The success rate and odds ratios were chosen to calculate the effect size for the meta-analysis.
Results
A total of nine publications were included for qualitative review and five of them were included in the meta-analysis. Around half of lesions that received annual or biannual application SDF ≥ 38% were arrested.
Conclusions
SDF 38% application was found to be effective in arresting dental caries progression in cavitated primary molars.
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References
Kassebaum NJ, et al. Global burden of untreated caries: a systematic review and metaregression. J Dent Res. 2015;94:650–658.
Arrow P, Forrest H, Piggott S. Minimally invasive dentistry: parent/carer perspectives on atraumatic restorative treatments and dental general anaesthesia to the management of early childhood caries. Front Oral Health. 2021;2:656530.
Cagetti MG, Angelino E. Could SARS-CoV-2 burst the use of Non-Invasive and Minimally Invasive treatments in paediatric dentistry? Int J Paediatr Dent. 2020;31:27–30.
Crystal YO, Niederman R. Evidence-based dentistry update on silver diamine fluoride. Dent Clin North Am. 2019;63:45–68.
Page MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Davies S. The importance of PROSPERO to the National Institute for Health Research. Syst Rev. 2012;9:1–5.
Sterne JAC, et al. RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
Fung M, Duangthip D, Wong M, Lo E, Chu C. Randomized clinical trial of 12 and 38% silver diamine fluoride treatment. J Dent Res. 2017;97:171–178.
Gao SS, et al. Arresting early childhood caries using silver and fluoride products—A randomised trial. J Dent. 2020;103:103522.
Abdellatif HM, Ali AM, Baghdady SI, ElKateb MA. Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: Randomized clinical trial. Eur Arch Paediatr Dent. 2021;22:575–585.
Llodra J, et al. Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. J Dent Res. 2005;84:721–724.
Mabangkhru S, Duangthip D, Chu CH, Phonghanyudh A, Jirarattanasopha V. A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride. J Dent. 2020;99:103375.
Tirupathi SP, Svsg N, Rajasekhar S, Nuvvula S. Comparative cariostatic efficacy of a novel Nano-silver fluoride varnish with 38% silver diamine fluoride varnish a double-blind randomized clinical trial. J Clin Exp Dent. 2019;11:e105–e112.
Vollú AL, et al. Efficacy of 30% silver diamine fluoride compared to atraumatic restorative treatment on dentine caries arrestment in primary molars of preschool children: A 12-months parallel randomized controlled clinical trial. J Dent. 2019;88:103165.
Zhi QH, Lo ECM, Lin HC. Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. J Dent. 2012;40:962–967.
Daga S, Shetty V, Hegde A. Silver diamine fluoride in arresting dentinal caries in school children. IJPHRD [Internet]. 2020;11:530–5. https://medicopublication.com/index.php/ijphrd/article/view/1218.
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Bonifácio, C.C., Hesse, D. Is silver diammine fluoride effective in arresting dental caries in cavitated primary molars?. Evid Based Dent 24, 50–51 (2023). https://doi.org/10.1038/s41432-023-00874-8
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DOI: https://doi.org/10.1038/s41432-023-00874-8