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Lipids and cardiovascular/metabolic health

Association between atherogenic index of plasma and subclinical renal damage over a 12-year follow-up: Hanzhong adolescent hypertension study

European Journal of Clinical Nutrition volume 74, pages 278–284 (2020)Cite this article

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Abstract

Background

A high atherogenic index of plasma (AIP) is associated with increased cardiovascular risk and higher serum uric acid levels, but whether AIP is a strong risk factor for developing subclinical renal damage (SRD) is unknown. This study aimed to explore the effect of AIP variations on the prevalence of SRD in a 12-year follow-up study.

Methods

(1) The cross-sectional study enrolled 2485 participants from the Hanzhong cohort in 2017; (2) A total of 202 participants were included in the small longitudinal cohort from 2005 to 2017. Longitudinal analysis was used to determine whether an elevated AIP predicts the development of SRD.

Results

In the cross-sectional analysis, the AIP level was correlated with the estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatine ratio (uACR) (P < 0.05). The age-adjusted odds ratio (OR) for prevalent SRD in men in the high AIP group was 1.924 (1.355–2.732) (P < 0.001), while in women, the OR was 1.616 (1.049–2.490) (P = 0.030) in the high AIP group. In the longitudinal analysis, significantly higher uACR levels were found in participants with normal AIP at baseline and elevated AIP in 2013 (P < 0.05). The adjusted OR for prevalent SRD in the incident AIP group was 4.741 (1.668–13.472) (P = 0.003) compared with the control group.

Conclusions

Our study indicates that elevated AIP increased the risk of developing SRD and was associated with uACR and eGFR. As a simple marker of CVD risk, AIP may emerge as a novel and reliable indicator of SRD.

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Acknowledgements

We are indebted to the participants in the study for their outstanding commitment and cooperation. This work was supported by the National Natural Science Foundation of China (No. 81570381 (J-JM), No. 81600327 (YW) and No. 81700368 (CC)), the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University of China (No. XJTU1AF-CRF-2017-021 (YW)), grants 2017YFC1307604 and 2016YFC1300104 from the Major Chronic Non-communicable Disease Prevention and Control Research Key Project of the Ministry of Science and Technology of the People’s Republic of China, and grant 2017ZDXM-SF-107 from the Key Research Project of Shaanxi Province. The sponsors and funding organizations had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

    Yue Yuan, Jia-Wen Hu, Yang Wang, Ke-Ke Wang, Wen-Ling Zheng, Chao Chu, Qiong Ma, Yu Yan, Yue-Yuan Liao & Jian-Jun Mu

  2. Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, China

    Yue Yuan, Jia-Wen Hu, Yang Wang, Ke-Ke Wang, Wen-Ling Zheng, Chao Chu, Qiong Ma, Yu Yan, Yue-Yuan Liao & Jian-Jun Mu

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Registration number for clinical trials: NCT02734472

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Yuan, Y., Hu, JW., Wang, Y. et al. Association between atherogenic index of plasma and subclinical renal damage over a 12-year follow-up: Hanzhong adolescent hypertension study. Eur J Clin Nutr 74, 278–284 (2020). https://doi.org/10.1038/s41430-019-0530-x

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