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Botryorhodines K and L, two new cytotoxic depsidones from a fungus of the genus Arcopilus

The Journal of Antibiotics volume 76, pages 673–677 (2023)Cite this article

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Abstract

Botryorhodines K (1) and L (2), two new depsidone derivatives, along with one known metabolite, 4-O-demethylbarbatic acid (3), were isolated from the culture extract of a fungus of the genus Arcopilus. The structures of 1‒3 were determined by the analysis of NMR and MS spectral data and the absolute configuration of 1 was established by single-crystal X-ray diffraction analysis. Compounds 1 and 2 showed antimicrobial activity against Gram-positive bacteria and cytotoxicity against murine leukemia P388 cells.

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Acknowledgements

P388 cells were obtained from JCRB Cell Bank under an accession code JCRB0017 (Lot. 06252002). We also thank Ms. Desy Wulan Triningsih at Toyama Prefectural University for cytotoxicity assay.

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Authors and Affiliations

  1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan

    Zhiwei Zhang, Yiwei Ge & Yasuhiro Igarashi

  2. Department of Physical Chemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki City, Osaka, 569-1094, Japan

    Yasuko In

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  1. Zhiwei Zhang
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  2. Yiwei Ge
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  3. Yasuko In
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  4. Yasuhiro Igarashi
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Correspondence to Yasuhiro Igarashi.

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Supplementary information

41429_2023_652_MOESM1_ESM.docx

Supplementary Information for Botryorhodines K‒L, two new cytotoxic depsidones from fungus of the genus<i> Arcopilus</i>

X-Ray crystallographic data for <b>1</b> (CIF)

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Zhang, Z., Ge, Y., In, Y. et al. Botryorhodines K and L, two new cytotoxic depsidones from a fungus of the genus Arcopilus. J Antibiot 76, 673–677 (2023). https://doi.org/10.1038/s41429-023-00652-9

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