Two new studies at the School of Dentistry University of Central Lancashire (UCLan) demonstrate that progress is being made in making much stronger connections between gum disease and deteriorating brain function.

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Alzheimer's disease is the most common type of dementia, progressively causing deterioration of memory, thinking skills and the ability to communicate. The exact cause of this disease is not yet fully understood, which means it's a difficult disease to prevent and treat.

It has been previously shown that the Porphyromonas gingivalis bacterium which destroys gum tissue - and the enzyme which it produces, known as gingipains - are specifically linked to Alzheimer's disease, after both were discovered in the brain tissue of those suffering from the disease. These new studies go a step further in exploring how gum disease and its bacterial proteins can potentially contribute to the formation of lesions on the brain.

The first study, to be published in the Journal of Alzheimer's Disease, shows that nerve cells in the brain contain a type of protein called tau. When tau meets the gingipains enzyme, the tau is released from the nerve cell. Once freed, tau physically changes, in the form of coils and non-coiling filaments. These filaments of tau then re-attach to the nerve cell and become incorporated into the lesion known as neurofibrillary tangles which ultimately kill the nerve cells.

These studies are small steps in the fight against Alzheimer's, but the results are significant in understanding the role of gingipains and how fundamental they are to lesion formation.

What this means is that once a nerve cell dies and the free tau protein leaks into the brain, the tau may attach itself to healthy neighbouring nerve cells, repeating the process and leading to further damage to the brain as the disease spreads.

The second study, published in the Journal of Alzheimer's Disease Reports, looks at the way the gingipains enzyme, released by the bacterium, can contribute to the formation of amyloid-beta plaques - another of the lesions, alongside the tangles, which form on the brains of those suffering from Alzheimer's.

These studies are small steps in the fight against Alzheimer's, but the results are significant in understanding the role of gingipains and how fundamental they are to lesion formation. It is hoped that studies such as these will help with developing future treatments.

Shalini Kanagasingam, Specialist Endodontist and Senior Clinical Lecturer at UCLan, who led the study, (supervised by Dr Sim K. Singhrao) said: 'What this kind of research proves is the importance of our oral health. Look out for early signs of gum disease such as bleeding gums when brushing or more advanced signs like movement or drifting of the teeth. Don't delay or skip your dental check-ups. Your dentist will be able to help advise you on how to effectively remove plaque and tartar from your teeth, which harbour the bacterium that we have identified as a risk factor for Alzheimer's. These studies highlight the key message that a healthy mouth is important for maintaining a healthy body and mind.'