Abstract
Introduction: Human bocavirus type I (HBoV1) is a member of the Parvoviridae family discovered in 2005. Recently, two new members have been recognized, HBoV2 and HBoV3. Its role as a pathogen in gastrointestinal diseases is not clear yet.
Methods: We analized the presence of bocavirus in the fecal samples of children belonging to a health area of approximately 40.000 children. We described the frequency of isolation of bocavirus with or without other viruses, their chronology and the clinical manifestations presented. Twenty strains were genotyped by a phylogenetic analysis of sequences obtained from a VP2 gene fragment.
Results: During the period from August of 2007 to January of 2010 were analized 1596 fecal samples, 195 (12,2%) were positive for bocavirus (51,5% in combination with other virus: adenovirus 28,1%, astrovirus 14,8%, calicivirus 10,2%, rotavirus 9,2%, CMV 0,5%). The average age was 2,4 years, the 71,9% of patients were younger than 3 years old and 56,1% of patients were boys,. The higher incidence was observed in October (28,6% of fecal samples were positive for bocavirus) and November (22,4% ratio). Clinical manifestations were: diarrhea (78,1%), abdominal pain (4,1%), fever (2%), pancreatitis (1%), anemia (1%). The inpatient ratio for bocavirus was 36,2%. Sequence analysis revealed that all of the 20 strains belonged to HBoV1.
Conclusions: Human bocavirus is often detected and associated with epidemic character (autumn) in stools of children with diarrhea. In a half of the cases appears coinfection with another virus. An unique genotype seems to be circulating
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Lobete, C., Lobeiras, A., Suárez, S. et al. 305 Bocavirus in Children with Gastroenteritis. Pediatr Res 68 (Suppl 1), 157 (2010). https://doi.org/10.1203/00006450-201011001-00305
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DOI: https://doi.org/10.1203/00006450-201011001-00305