Abstract
Background: The spontaneous breathing rate (SRR) response to different tidal volume setting during volume guarantee ventilation (VG) combined with flow cycled ventilation, (PSV) could represent an adequate response in keeping a constant mminute volume ventilation, and probably correlates with PaCO2 variations.
Objective: To investigate the effect of different VT settings in the spontaneous respiratory rate (SRR), respiratory rate/tidal volume ratio (RVR), minute volume ventilation and lung mechanics.
Design/Methods: Six newborn piglets were ventilated with a Dräger BB8000+ ventilator in PSV with spontaneous breathing and VG initially set at 4 ml/kg of VT and increased in 10 min intervals in 1 ml/kg until a VT of 10 ml/kg. with normal lungs and after artificial RDS induced with a BAL. Respiratory mechanics, heart rate and blood pressure were continuously recorded and arterial blood gas measured after each 10 min intervals.
Results: SRR, RVR and PaCO2 decreased after increase in VT, in normal lung (p< 0.05). In the RDS lung, SRR, RVR and PaCO2 increased by decreasing VT settings (p< 0.05). Minute volume inversely correlated with SRR (p< 0.05).
Conclusions: In this animal model, during PSV with VG ventilation in normal lungs and after BAL, changes in VT induced inverse changes in the SRR. The SRR and RVR value could be an important guide to know if the setting VT during VG with PSV is adequate or not.
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Luna, S., Santos, M. & Tendillo, F. 1352 Volume Guarantee Setting and Spontaneous Respiratory Rate Response in a Neonatal Animal Model of Rds. Pediatr Res 68 (Suppl 1), 669 (2010). https://doi.org/10.1203/00006450-201011001-01352
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DOI: https://doi.org/10.1203/00006450-201011001-01352