Abstract
Background:The literary information about vitamin D saturation in newborns is rare. Levels of vitamin D in healthy term newborns in the Czech Republic have not been examined yet. The vitamin D saturation in newborns depends mainly on maternal saturation during gravidity that may be decreased due to nutritional habits and climatic conditions in the Middle Europe.
Objective: To get comparative values for examining of bone metabolism in newborns with very-low-birth weight.
Design: A prospective study conducted in spring period 2006 in a cohort of 28 healthy term caucasian newborns with normal birth weight. Blood and urine samples were drawn at the age of 3-7 days for examination of 25-hydroxyvitamin D (25/OH/D), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), osteocalcin (OC), intact parathormone (PTH) in serum and calcium and phosphate in urine.
Results: Though other parameters of Ca and P metabolism were in normal range, levels of 25/OH/D were considerably lower than reference values found in literature. A significant correlation was found between 25/OH/D level and OC level, and futher a negative correlation (but not significant) of 25/OH/D and PTH.
Conclusion: Term newborns in the Czech Republic are born with an insufficient supply of vitamin D in the spring period obviously. The significant correlation of 25/OH/D level with bone formation marker (OC) and the tendency to higher PTH concentrations in newborns with lower 25/OH/D levels support the premise of an adverse effect of low vitamin D supply on long-term bone development.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dort, J., Bayer, M., Dortova, E. et al. 1030 Vitamin D and Other Parameters of Calcium and Phosphate Metabolism in Healthy Term Newborns After Birth. Pediatr Res 68 (Suppl 1), 512 (2010). https://doi.org/10.1203/00006450-201011001-01030
Issue Date:
DOI: https://doi.org/10.1203/00006450-201011001-01030