Abstract
Objectives; The purpose of this study is to clarify the long-term outcome of patients with Kawasaki disease(KD). Methods; We investigated the outcomes of the patients with KD who were examined in our institute and already reached eighteen years old by reviewing their clinical records. Results; 375 patients with KD(female/male; 140 / 235)reached eighteen years old, fifty-two of them are followed up regularly. Their ages range from 18 to 31 years old (median; 21years old). Age at onset of KD is 1.8 (median)years old(0.2∼11.8 years old). Thirty-eight patients(10%) had coronary artery lesions on the first examination, Twelve(32 %) of them developed stenotic lesions, and ten of them(26 %) were regressed later. Three patients had aneurysmal lesions of another arteries in addition to coronary artery lesions, two of them had an aneurysm in iliac artery and one of them had in bilateral axillary arteries and abdominal aorta. Myocardial infarction occurred in five patients (1%). One patient suddenly died while walking at the age of eighteen. Epileptic attack occurred in two patients, one of them was resulted from the cerebral infarction at the onset. Acute leukemia developed later in two patients. Nineteen patients were managed with prophylactic anticoagulant medications (antiplatelet agents), and five of them also received a vasodilator. The medications were omitted in four male patients. Conclusions; KD patients with coronary artery lesions presented a variety of clinical course, therefore an appropriate management and a carefull follow-up are considered to be necessary.
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Waki, K., Baba, K., Arakaki, Y. et al. Long-term Outcome of Patients with Kawasaki Disease. Pediatr Res 53, 185 (2003). https://doi.org/10.1203/00006450-200301000-00191
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DOI: https://doi.org/10.1203/00006450-200301000-00191