Abstract
To assess the overall outcome of Kawasaki disease, patients with a discharge diagnosis of Kawasaki disease at Korea University Medical Center from 1999 to 2001 were retrospectively evaluated. A total of 99 patients were diagnosed. The American Heart Association (AHA) criteria were met in 65 patients (66%) and 63 of them received intravenous immune globulin (IVIG, 2g/kg). Fifty patients responded afebrile within 5 days (IVIG-responsive) and 13 patients did not (IVIG-non-responsive). Within 2 months, 2 patients in the IVIG-responsive group developed coronary abnormalities compared to 3 patients in the IVIG-non-responsive group (4% vs 23%). None of whom met AHA criteria and did not received IVIG were febrile more than 5 days nor developed coronary abnormalities. In 34 patients who did not meet complete AHA criteria, 28 patients received IVIG and 25 patients were IVIG-responsive. Coronary abnormalities were developed in 4 in the IVIG-responsive group compared to none in the IVIG-non-responsive group (16% vs 0%). All 6 patients who did not meet complete AHA criteria and did not received IVIG were febrile more than 5 days and 2 of them developed coronary abnormalities. Taken together, coronary abnormalities were developed in 9 patients of 91 who were treated with IVIG compared to 2 patients of 8 who were not treated with IVIG (10% vs 25%). In conclusion coronary abnormalities were developed in 11 of 99 patients with Kawasaki disease (11%).
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Lee, J., Lee, K., Son, C. et al. Overall Outcome of Kawasaki Disease. Pediatr Res 53, 176 (2003). https://doi.org/10.1203/00006450-200301000-00135
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DOI: https://doi.org/10.1203/00006450-200301000-00135