Abstract 854 Poster Session II, Sunday, 5/2 (poster 147)

Between January 1, 1960 and December 31, 1989, 182 previously untreated patients with Hodgkin disease who were less than 20 years of age at diagnosis were referred for treatment. There were 100 males. 176 were Caucasian. 106 underwent splenectomy. 83 had one or more relapses of Hodgkin disease after their initial course of therapy. The age at diagnosis was 15.30 (S.D. 3.67) years. The duration of survival after diagnosis was 17.01 (S.D. 9.65) years. 5 Caucasian patients who were treated with radiation therapy developed basal cell carcinoma as a SMN at the ages of 29.5 - 46.2 years, 17.78 (S.D. 6.46)(range 12.67 - 28.08) years after diagnosis of Hodgkin disease. Two patients developed multiple basal cell carcinomas 0.2 to 1.6 years after diagnosis of the first basal cell carcinoma. The cumulative percentage of patients who developed basal cell carcinoma was: radiation therapy (RT) only - 2.9% at 14.03 years, chemotherapy (CT) only - 0%, and RT + CT - 5.6% at 20.17 years (p=0.9578, log-rank). Univariate log-rank analyses of Kaplan-Meier plots of gender (p = 0.1621), RT (p = 0.7753), CT (0.9665), relapse (p = 0.2958) and splenectomy (p = 0.18) with basal cell carcinoma as an SMN gave non-significant results. Children and adolescents who have been treated successfully for Hodgkin disease should be advised regarding their risk of subsequent non-melanoma skin cancer. Medical follow-up should include thorough examination of the skin and teaching regarding safe sun exposure.