Abstract 125

Aims: To use amplitude integrated EEG (aEEG) objectively to select infants for hypothermic treatment (33-34oC rectal temperature for 48 hours) within 6 hours birth asphyxia and to seek adverse effects.

Methods: 11 asphyxiated infants were assessed and the 6 infants with abnormal aEEG were treated with hypothermia and multiple variables monitored.

Results: Treated infants were born at 34-40 weeks, with Apgar score of 0-4 at 5 minutes and blood pH 6.54-6.78. No alterations in coagulation, viscosity, packed cell volume or cardiac function were observed but mild hypokalaemia (<3.5 mmol/L) was seen in four infants. One infant developed haemorrhagic cerebral infarction and died; another showed a small cerebellar infarct. Magnetic resonance imaging and assessment at 1-12 months was compatible with a normal outcome in the remaining 9 infants.

Conclusion: Infants can be selected and treated within 6 hours of birth asphyxia. 48 hours of whole body cooling to 33-34oC appears to be safe.