Routine newborn care includes the prophylactic administration of Vitamin K to the baby at birth to prevent the occurrence of Hemorrhagic Disease of the Newborn (HDN). A single dose of Vitamin K1 administered intramuscularly (IM) has been the standard practice in the Philippines. In instances when the IM route may not be acceptable of feasible, an alternative route for Vitamin K prophylaxis is the oral route, in the form of Vitamin K2 (Kaytwo Syrup). A study was conducted at the Philippine General Hospital among eighty (80) healthy fullterm breastfed neonates to determine the efficacy of multiple doses of oral Vitamin K2 in the prophylaxis of HDN (oral group), and compare it with that of a single dose of intramuscular Vitamin K1 (IM group). 40 babies were assigned to the oral group while another 40 babies were assigned to the IM group. The oral group received 3 doses of Vitamin K2 at birth, at Day 7, and at Day 30. The coagulation activities of the babies in the two groups were measured using the Hepaplastintest (HPT) before Vitamin K, at least 6 hours after Vitamin K, at Day 2, Day 7, Day 14 and Day 30. Statistical analyses were performed utilizing the two-factor experiment with repeated measurements on the factor, and Duncan's multiple range test. Results showed that oral Vitamin K2 is generally comparable in efficacy to intramuscular Vitamin K1 in the prevention of HDN. Advantages of oral Vitamin K2 include its ease of administration and lower cost. It is very safe, and its taste is quite acceptable by the babies. We therefore recommend the use of oral Vitamin K2 as an alternative choice for Vitamin K prophylaxis in the newborn.