ACTION OF RADIATION AND CHEMICAL FACTOR ON RED CELL MEMBRANE IN CHILDREN WITH ANEMIC SYNDROME 114

244 children from different regions of Belarus were evaluated. The scheme of examination included common pediatric examination, RBC, Hb, Ht and reticulocyte measurement as well as ferrokinetics. The group of children with anemic syndrome was separated. Evaluation of endoecological status, investigation of red cell kinetics and biophysical characteristics of red cell membranes were performed. The children with anemic syndrome were divided into four groups due to endoecological status: lead (Pb) serum level, mercury (Hg) serum level and Cs¹³⁷. Children with higher blood level of 3 toxins(Pb, Hg, Cs¹³⁷) were included in the first group. The second group comprised of children with increased blood level of Pb and Hg. The third and fourth groups consisted of children with higher blood level of Pb and Hg respectively. The red cell membrane state was evaluated by relative quantum outcome of inner tryptophane luminescence of red cell membranes. It characterizes the state of red cell membrane's protein (l_registration=345 nm; l_action=297 nm). The physical state of lipid layer was evaluated by means of lipofilic zond pyren. The protein concentration in membrane's suspension was 0.08 mg/ml and in pyren-5.5, 10^-6 M. Kinetic analyses revealed increase of daily hemolysis and activation of daily erythropoesis in children of the 1st and 2nd groups. This fact showed noneffective erythropoesis because there was no clinical manifestation of hemolysis. The increase red cell hypochromia created a condition for formation of fast destroyed population of red cells. It signified the decrease of red cell's life. There was no marked disturbances of microviscosity of lipid bilayer. There were marked changes in protein membrane's condition in the first group of children and unmarked changes of the 2nd and the 3rd group. Thus, red cell membrane is susceptible to a combined effect of PBS, Hg and Cs¹³⁷.