Background: We studied the effects of gestational age (GA) and intra-uterine or post-natale hypoxia on first feed mesenteric adaptation in premature infants.
Study type: Prospective cohort study in a tertiary neonatal service
Patients: 34 newborn: GA less than 32 weeks - median 30 - mean birthweight 1262 g (820-2200)
Intervention: At a median age of 8 days, superior mesenteric blood flow velocity was assessed by doppler echography before and 30 minutes after 3 to 5 ml/kg of human milk (naso-gastric feeding)
Results:
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Post prandialy, there was a significant (p < 0,01) increase in mesenteric artery systolic (26%), mean (31%) and diastolic (54%) velocities.
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Gestational age, intra-uterine growth retardation, acute asphyxia(evaluated by intrapartum monitoring, Apgar score, plasma lactate), early post-natal respiratory distress or hypotension did not influence mesenteric velocities changes.
Conclusion: In very preterm infants, at the end of the post-natal first week, we found a significant mesenteric blood flow increase in response to feeding, independantly of perinatal hypoxia.
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D. Rieu (spn. by C. Sultan)
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Cambonie, G., Luc, F., Montoya, F. et al. Mesenteric Blood Flow in Premature Infants 46. Pediatr Res 40, 522 (1996). https://doi.org/10.1203/00006450-199609000-00069
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DOI: https://doi.org/10.1203/00006450-199609000-00069