Abstract
This national program has detected 35 patients in the Metropolitan Region and 6a Region, from March, 1992 until May, 1994. Tne observed incidence is 1/4316.
Objective: Psychometric and neurological evaluation of the subjects detected. Method: Psychometric evaluation by psychologist, applying Bayley scales and neurological evaluation by pediatric neurologist, at 2-6-10-12-18-24 months of age. Results: Out of 33 children: 24 had initial low T4, 6 had compensated hypothyroidism (HCT) and 3 had delayed hypothyroidism (HCT). Out of 24 patients, 23 began their treatment at an average age of 16 days. Initial T4 was 5.85 μg/dL (range: 1.0-9.9). Psychometry was normal at all ages. One case was treated at 73 days, with T4 0.1 pg/dL and had altered psychometry, which tended to improve later on. Comparing six patients with delayed bone age (BA) and average T4 2.65 pg/dL (range: 0.1-4.8) with 18 patients with normal bone age and average T4 5.85 μg/dL (range: 1.0-9.9) psychometry was normal in both groups, but tended to have higher scores in the cases with normal BA. All HC and HCT psychometric tests were normal, except in one who had a marginal score at 3 months of age. Neurological examination was abnormal in 3 out of 24: one whose treatment was delayed, one preterm child with a pyramidal syndrome at 3 months of age, and 1 with slight psychomotor delay at 3 months of age.
Conclusions: 1.- After 18 months of observation the psychometric tests were normal when treatment was started before the age of 30 days. 2.- Delayed (BA) and low T4 level (< 4.28 μg/dL) may predict retarded psychomotor development. 3. - It is necessary to have longer follow up in order to predict psychomotor development.
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Cuello, X., Abodovsky, N., Vivanco, X. et al. CHILEAN SCREENING PROGRAM FOR CONGENITAL HYPOTHYROIDISM. PSYCHOMETRIC AND NEUROLOGICAL EVALUATION OF DETECTED CASES. Pediatr Res 38, 625 (1995). https://doi.org/10.1203/00006450-199510000-00047
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DOI: https://doi.org/10.1203/00006450-199510000-00047