Abstract
We studied 15 girls and 1 boy with CPP, divided in 2 groups according to BA in the moment of withdrawn of treatment (tto). In group A the tto was stopped with BA between 11 and 12.9 years and group B between 13 and 15 years. BA and stature were obtained in 3 different occasions: at beginning, at the end of tto and in the last evaluation (mean 2 years after tto was stopped). Stature was expressed in standard-deviation score related to BA: 2s. Results:: In group A the differences between patients Zs and parents stature were: 0.003, -0.11 + respectively in the first, second and third evaluation. In group B these values were -4.53, 1.12, -0.53.
Z ini=Zs from the beginning of tto; Z tto=Zs at stopped tto;Z fin=Zs at last evaluation. Variation of Zs >0.5 was considered significant. In group A 2/7 patients improved their Zs between the first and second evaluations, and 2/7 between the second and third. There was a decrement of Zs in 1/7 patients in each period. In group B 4/8 patients improved their Zs between the first and second evaluation and 6/9 between second and third. Decrement of Zs was observed tn 1/8 patients between first and second evaluation and 1/9 between second and third. There was a greater tendency to improve the Zs in group B in relation to group A, suggesting that premature treatment whitdrawn can compromise the final stature.
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Calliari, L., Rodrigues, A., Refinetti, C. et al. 35 BONE AGE(BA) AT THE END OF TREATMENT IN CENTRAL PRECOCIOUS PUBERTY (CPP): IMPACT OVER STATURE. Pediatr Res 36, 684 (1994). https://doi.org/10.1203/00006450-199411000-00093
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DOI: https://doi.org/10.1203/00006450-199411000-00093