Abstract
We evaluated the plasma levels of IGF-I in 33 girls with sexual precocity to assess its efficacy as a discriminating diagnostic tool berween precocious puberty and variants of pubertal development (pubarche and thelarche). The assays were performed using an extraction process, IGF-I levels were elvated in 5 cases of precocious puberty. They averaged 0.87 ± 0.38 U/ml in precocious puberty, 0.63 + 0.21 U/ml in pubarche and 0.47 ± 0.14 U/ml in thelarche. There was a significant difference (p < 0.05) between levels of IGF-I in precocious puberty and thelarche by the Bonferroni test. We conclude that the isolated determination of IGF-I is not a discrimating diagnostic test between the forms of sexual precocity. Elevated levels can be useful, suggesting the diagnosis of precocious puberty.
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Carvalho, M., Teixeira, R., Freitas, J. et al. 30 INSULIN LIKE GROWTH FACTOR-I IN SEXUAL PRECOCITY. Pediatr Res 36, 683 (1994). https://doi.org/10.1203/00006450-199411000-00088
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DOI: https://doi.org/10.1203/00006450-199411000-00088