Abstract
To study the influence of IGF-1 and IGF-2 levels in the catch-up-growth(CUG) of small for gestational age (SGA) infants, we followed 32 newborns (18 boys and 14 girls) with birth weight of 2344±195 g and birth length of 45.7 ± 2 cm. during the first year of life. We measured weight, lenght, IGF-1 and IGF-2 at 0, 3,6,9 and 12 months of age. CUG was defined as an increase in lenght 2 score greater than 1 SD at 6 months of age, based upon the fact that accelerated growth, when observed in CUG (+) infants, occurs during this period. We compared the concentrations of IGF-1 and 2 between the infants who demostrated evidence of CUG and those who did not.
Height Z score was lower in CUG(+)infants at birth and increased during the first 6 months of life. IGF -2 levels were significantly greater at 3 and 6 months in CUG (+) infants. These were no differences in IGF-2 levels at 0, 9, 12 months, nor in IGF-1 levels at any time. We conclude that circulating IGF-2 levels at 3 and 6 months correlate with height velocity. This growth factor may be involved in the mechanism of CUG in SGA age infants. This suggests that IGF-2 may be useful as a potential therapeutic agent for the treatment of SGA infants who do not demostrate evidence of CUG. Financial support: Grant 91-1274, Fondecyt.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Garcia, H., Henriquez, C., Ugarte, F. et al. 24 THE CIRCULATING LEVELS IGF-2 ARE INCREASED IN SMALL FOR GESTATIOINAL AGE (SGA) INFANTS WHO SHOW EVIDENCE OF CATCH-UP-GROWTH (CUG) DURING THE FIRST YEAR OF LIFE. Pediatr Res 36, 682 (1994). https://doi.org/10.1203/00006450-199411000-00082
Issue Date:
DOI: https://doi.org/10.1203/00006450-199411000-00082