Abstract
We have previously reported that prepubertal diagnosis of HH could be assumed on the basis of micropenis and cryptorchidism, olfactory disturbances, low LH response to GnRH infusion and subnormal clinical and histological response to prolonges treatment with hCG.
In order to confirm the diagnosis of HH at pubertal age, 12 patients with suspicious prepubertal diagnosis of HH were studied, due to the clinical appearance, hCG test; Testosterone (T: ng/dl) basal: 31.9 ± 25.9, T post hCG: 111 ± 97.8 and with GnRH infusion (0.83 ug/min): LH (IU/L) basal: 2.8 ± 1.9, LH Max: 7.5 ± 3.9; FSH (IU/L) basal: 2.1 ± 1.9, FSH Max: 5.1 ± 2.8.
In all patients the clinical diagnosis of HH was confirmed at the last control carried out at the age of 17.17 ± 2.18 years. Their height was 170.6 ± 5.62 cm, testicular volume 2.11 ± 0.93 ml and anosmia was detected in 6 out of 12. All of them required therapy with exogenous testosterone.
These results demonstrate the wtilily of hormonal tests for the prepubertal diagnosis of HH in boys with micropenis and cryptorchidism.
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Ropelato, G., Bergadá, C. 5 CONFIRMATION OF HYPOGONADOTROPIC HYPOGONADISM (HH) SUSPECTED AT PREPUBERTAL AGE. Pediatr Res 36, 679 (1994). https://doi.org/10.1203/00006450-199411000-00063
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DOI: https://doi.org/10.1203/00006450-199411000-00063