Abstract
The growth pattern of a population of 254 patients with TS, seen between 1960 and 1992, was analyzed and their data compared with those of normal girls and of other TS series, in order to have local reference parameters. A combination of cross-sectorial and longitudinal data consisting of 2308 height determinations was studied. Mean birth weight of 156 term infants was (X±SD) 2812 ± 487 grs, significantly reduced when compared to normal controls 3340 ± 490 grs (p < 0.001). The mean birth lenght of 14 patients was 46.7 ± 2.67 cm below the mean of the control group: 50.0 ± 1.80 cm (p < 0.001). Our data shows moderate growth retardation already apparent at birth; lenght -1.77 SDS. This difference increase in the first year of life to -2.91 SDS, stabilizes up to 10 years -2.48 SDS, and then increases again during pubertal age up to reach a final height of 138.7 ± 5.46 cm at -3.62 SDS of the mean normal adult stature, different from that of other TS populations. Positive correlation between final and target height was found (r=0.42 p < 0.004) in a group of 44 patients.
Conclusion: The growth pattern of patiens with Turner Syndrome studied is similar to that of other reported TS populations. The observed differences may be explained by height differences between normal female populations.
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Garcia, C., Martinez, A., Keselman, A. et al. 6 GROWTH IN TURNER SYNDROME. (TS). Pediatr Res 36, 673 (1994). https://doi.org/10.1203/00006450-199411000-00030
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DOI: https://doi.org/10.1203/00006450-199411000-00030