Abstract
An abnormality in spontaneous GH secretion has been suggested in children with short stature. Twenty eight prepubertal children were studied. Group A: Nine short children, with normal growth velocity and a normal response to provocative tests for GH(≥10 ng /ml), chronological age(CA)(X±SD)9.51±2.95 years, bone age(BA) 7.45 ± 3.84. Group B: 15 children with short stature, subnormal growth velocity and normal GH response, CA 11.39±2.27 and BA 8.98±2.55. Group C:4 children with idiapathic GH deficiency. CA 12.27±3.60, BA 10.6±2.95. Spontaneous overninght GH levels were obtained. GH was measured by RIA. Mean 12 hrs. GH levels(XGH), GH amplitude(A), frecuency (F)and the highest spontaneous GH peak(MxE) were analyzed.
A correlation between XGH and MxE was found (r=0.79, p<0.001). No correlation between XGH and growth velocity could be observed. The 99 percent confidence limits for XGH in group A were 2.91 to 5.99 ng/ml. Four children of group B had XGH below this limit, with values similar to the children with GH deficiency. In these 4 children the MxE was also below the 99 percent confidence limit. This results suggest a GH secretory disturbance in these 4 children, but not in the other patients of groups B in whom the pattern of secretion did not differ of that of children growing normally.
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Martinez, A., Ropelato, G., Heinrich, J. et al. 2 GROWTH HORMONE (GH) SPONTANGEOUS SECRETION IN CHILDREN WITH SHORT STATURE (SS). Pediatr Res 36, 672 (1994). https://doi.org/10.1203/00006450-199411000-00026
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DOI: https://doi.org/10.1203/00006450-199411000-00026