Abstract
In order to evaluate the effects of slow-release gonadotropin-releasing hormone analogues on calcium metabolism, we studied 10 (7 female, 3 male) children with central precocious puberty, treated with GnRH agonist D-Trp6-GnRH (Decapeptyl, Ipsen), their mean ± SD age was 5.5 ± 3.1 years. The patients were studied before the beginning (t0) and after 6 months of treatment (t1). Twelve sex and age-matched healthy children were also studied. We evaluated Bone Mineral Content (BMC) and serum levels of calcium, phosphorus, magnesium, PTH (M 44-68), CT, 25-OH-vitamin D
At t0, the 24 hour excretion of calcium, phosphorus and magnesium were similar to control group and did not changed at 11. Our study shows that children with precocious puberty have an increased BMC and that gonadotropin-releasing hormone analogues modify bone density, with a consequent its reduction; this reduction seems not related to calcium metabolism.
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Verrotti, A., Magri, M., Chiarelli, F. et al. 240 CALCIUM METABOLISM IN CHILDREN WITH PRECOCIOUS PUBERTY TREATED WITH GnRH AGONIST. Pediatr Res 36, 42 (1994). https://doi.org/10.1203/00006450-199407000-00240
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DOI: https://doi.org/10.1203/00006450-199407000-00240